Diagnostic and prognostic value of the cancer-testis antigen lactate dehydrogenase C4 in breast cancer

•LDHC mRNA and protein are up-regulated in BC.•Serum or exosomal LDHC is a powerful indicator in the management of patients with BC.•LDH-C4 serves as a promising prognostic biomarker for BC. Lactate dehydrogenase C4 (LDH-C4) as a cancer/testis antigen (CTA) is abnormally expressed in some malignant...

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Bibliographic Details
Published in:Clinica chimica acta 2020-04, Vol.503, p.203-209
Main Authors: Cui, Zhaolei, Chen, Yansong, Hu, Minhua, Lin, Yingfeng, Zhang, Shuyu, Kong, Lingying, Chen, Yan
Format: Article
Language:English
Subjects:
Breast cancer
Diagnosis
Exosome
Lactate dehydrogenase C4
Prognosis
Serum
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Summary:•LDHC mRNA and protein are up-regulated in BC.•Serum or exosomal LDHC is a powerful indicator in the management of patients with BC.•LDH-C4 serves as a promising prognostic biomarker for BC. Lactate dehydrogenase C4 (LDH-C4) as a cancer/testis antigen (CTA) is abnormally expressed in some malignant tumors. However, the expression and clinical significance of LDH-C4 in breast cancer (BC) has not been characterized. We determined LDHC mRNA expression in serum and serum-derived exosomes of BC patients by quantitative RT-PCR. We also evaluated the protein expression of LDH-C4 in BC tissues using high-throughput tissue microarray analysis and immunohistochemistry. Our results showed high mRNA expression level of LDHC in serum and serum-derived exosomes of BC patients. The LDHC level in serum and exosomes could distinguish BC cases from healthy individuals based on their AUCs of 0.9587 and 0.9464, respectively. Besides, the LDHC level in exosomes of BC patients associated with tumor size, and positively correlated with HER2 and Ki-67 expressions (all with P 
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2019.11.032