Impact of NAFLD on the Incidence of Cardiovascular Diseases in a Primary Care Population in Germany

Background Patients with NAFLD are considered at a high risk of cardiovascular events due to underlying metabolic risk factors. Currently, data related to the impact of NAFLD on cardiovascular risk in the general population are lacking. Aims The aim of this study was to investigate the role of NAFLD...

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Bibliographic Details
Published in:Digestive diseases and sciences 2020-07, Vol.65 (7), p.2112-2119
Main Authors: Labenz, Christian, Huber, Yvonne, Michel, Maurice, Nagel, Michael, Galle, Peter R., Kostev, Karel, Schattenberg, Jörn M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Atrial Fibrillation - epidemiology
Biochemistry
Cardiac arrhythmia
Cardiovascular disease
Cardiovascular Diseases - epidemiology
Comorbidity
Coronary Disease - epidemiology
Diabetes Mellitus - epidemiology
Female
Gastroenterology
Germany - epidemiology
Health risk assessment
Heart attacks
Hepatology
Humans
Hyperlipidemias - epidemiology
Hypertension - epidemiology
Incidence
Male
Medicine
Medicine & Public Health
Metabolic syndrome
Middle Aged
Myocardial Infarction - epidemiology
Non-alcoholic Fatty Liver Disease - epidemiology
Oncology
Original Article
Primary care
Primary Health Care
Proportional Hazards Models
Regression analysis
Risk Factors
Sex Factors
Stroke
Stroke - epidemiology
Transplant Surgery
Young Adult
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Summary:Background Patients with NAFLD are considered at a high risk of cardiovascular events due to underlying metabolic risk factors. Currently, data related to the impact of NAFLD on cardiovascular risk in the general population are lacking. Aims The aim of this study was to investigate the role of NAFLD on risk of myocardial infarction (MI), coronary heart disease (CHD), atrial fibrillation (AF), and stroke in primary care in Germany. Methods The study included patients diagnosed with NAFLD in primary care between 2010 and 2015. NAFLD cases ( n  = 22,048) were matched to a cohort without NAFLD ( n  = 22,048) based on age, sex, treating physician, type 2 diabetes, arterial hypertension, and hyperlipidemia. The primary outcome of the study was the incidence of MI, CHD, AF, and stroke. Results Within 10 years of the index date, 12.8% of patients with NAFLD and 10.0% of controls were diagnosed with CHD ( p  
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-019-05986-9