COMPARISON OF THE RADIATION SENSITIVITY OF THE BREAST CANCER CELL LINE MCF7 AND HUMAN ADIPOSE-DERIVED STEM CELLS

A comparison between breast cancer cell line MCF7 and human adipose-derived stem cells (ADSC) after irradiation by the same doses of megavoltage X-rays was performed. The cell growth, the induction of apoptosis and the expression of selected genes were analyzed. Irradiated MCF7 related to its contro...

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Bibliographic Details
Published in:Radiation protection dosimetry 2019-12, Vol.186 (2-3), p.155-158
Main Authors: Michaelidesová, Anna, Vachelová, Jana, Cupal, Lukáš, Konířová, Jana, Brabcová, Kateřina Pachnerová, Bačáková, Lucie, Vandrovcová, Marta, Davídková, Marie
Format: Article
Language:English
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Summary:A comparison between breast cancer cell line MCF7 and human adipose-derived stem cells (ADSC) after irradiation by the same doses of megavoltage X-rays was performed. The cell growth, the induction of apoptosis and the expression of selected genes were analyzed. Irradiated MCF7 related to its control sample grows slower than ADSC and it undergoes apoptosis in much higher levels than ADSC. This was confirmed by real-time polymerase chain reaction as well, where the expression of apoptotic genes was found to be considerably higher for MCF7 than for ADSC. From the results of this project, it could be stated that MCF7 is more radiosensitive than ADSC.
ISSN:0144-8420
1742-3406
DOI:10.1093/rpd/ncz193