Ag@TiO2 Nanoprisms with Highly Efficient Near‐Infrared Photothermal Conversion for Melanoma Therapy

Melanoma is a primary reason of death from skin cancer and associated with high lethality. Photothermal therapy (PTT) has been developed into a powerful cancer treatment technique in recent years. Here, we created a low‐cost and high‐performance PTT agent, Ag@TiO2 NPs, which possesses a high phototh...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2020-01, Vol.15 (1), p.148-155
Main Authors: Nie, Chuang, Du, Peng, Zhao, Hongwei, Xie, Hainan, Li, Yuxin, Yao, Li, Shi, Yuanyuan, Hu, Lianna, Si, Shaoyan, Zhang, Maonian, Gu, Jianwen, Luo, Ling, Sun, Zaicheng
Format: Article
Language:English
Subjects:
Ag@TiO2 nanoprisms
Biocompatibility
Cancer
Cell death
Chemistry
Cytotoxicity
High temperature
Lethality
Light irradiation
Melanoma
melanoma therapy
nanomedicine
Photothermal conversion
photothermal therapy
Skin cancer
Sol-gel processes
Therapy
Titanium dioxide
Toxicity
Tumors
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Summary:Melanoma is a primary reason of death from skin cancer and associated with high lethality. Photothermal therapy (PTT) has been developed into a powerful cancer treatment technique in recent years. Here, we created a low‐cost and high‐performance PTT agent, Ag@TiO2 NPs, which possesses a high photothermal conversion efficiency of ≈65 % and strong near‐infrared (NIR) absorption about 808 nm. Ag NPs were synthesized using a two‐step method and coated with TiO2 to obtain Ag@TiO2 NPs by a facile sol‐gel method. Because of the oxide, Ag@TiO2 NPs exhibit remarkable high photothermal conversion efficiencies and biocompatibility in vivo and in vitro. Cytotoxicity and therapeutic efficiency of photothermal cytotoxicity of Ag@TiO2 NPs were tested in B16‐F10 cells and C57BL/6J mice. Under light irradiation, the elevated temperature causes cell death in Ag NPs‐treated (100 μg mL−1) cells in vitro (both p
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.201901394