Harnessing microbial metabolomics for industrial applications

Metabolome defines a set of metabolites present in a biological sample, which provides an immediate and dynamic recording of microbes in response to genetic and/or environmental perturbations. In recent years, metabolomics in combination with other omics diagnostic tools such as genomics, transcript...

Full description

Saved in:
Bibliographic Details
Published in:World journal of microbiology & biotechnology 2020-01, Vol.36 (1), p.1-1, Article 1
Main Authors: Zhao, Jiachen, Wang, Guan, Chu, Ju, Zhuang, Yingping
Format: Article
Language:English
Subjects:
Amino acids
Amino Acids - metabolism
Anti-Bacterial Agents - metabolism
Antibiotics
Applied Microbiology
Biochemistry
Biofuels
Biomedical and Life Sciences
Biotechnology
Computational Biology
Databases, Factual
Diagnostic software
Diagnostic systems
Environmental Engineering/Biotechnology
Enzymes - metabolism
Fermentation
Genomics
Industrial applications
Industrial Microbiology - methods
Life Sciences
Metabolic Engineering
Metabolism
Metabolites
Metabolome
Metabolomics
Metabolomics - methods
Microbiology
Microorganisms
Optimization
Organic acids
Proteomics
Review
Synthetic biology
Systems Biology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Metabolome defines a set of metabolites present in a biological sample, which provides an immediate and dynamic recording of microbes in response to genetic and/or environmental perturbations. In recent years, metabolomics in combination with other omics diagnostic tools such as genomics, transcriptomics and proteomics is focused on addressing open biological questions that accelerate our understanding of the system as a whole and boost the use of systems metabolic engineering tools in industrial settings. In this review article, we summarize the applications of metabolomics to industrial microbial fermentations with respect to the bulk production of organic acids, amino acids, enzymes, antibiotics and therapeutic proteins. In addition, future prospects regarding metabolomics-assisted research are provided.
ISSN:0959-3993
1573-0972
DOI:10.1007/s11274-019-2775-x