Histological characterization of the lingual tonsils of the one-humped camel (Camelus dromedarius)

• Published in: Cell and tissue research 2020-04, Vol.380 (1), p.107-113
• Main Authors: Zidan, Mohamed, Pabst, Reinhard
• Format: Article
• Language: English
• Subjects: Antigens; Biomedical and Life Sciences; Biomedicine; Camelidae; Dendritic cells; Epithelium; Human Genetics; Immunology; Lymphocytes; Lymphoid tissue; M cells; Macrophages; Molecular Medicine; Nodules; Oropharynx; Plasma cells; Proteomics; Regular Article; Tonsil
• ISSN: 0302-766X; 1432-0878
• DOI: 10.1007/s00441-019-03135-2

Tonsils are located in the entrance of digestive and respiratory tracts forming Waldeyer’s ring that reacts against ingested or inhaled antigens. On occasion, tonsils may be a site of entry and replication for some pathogens. The lingual tonsils are a main constituent of the Waldeyer’s ring. Despite the immunological importance of the lingual tonsils, there is limited information about their structure in the one-humped camel. The lingual tonsils of 10 clinically healthy male camels (3–25 years) were collected and studied macroscopically and microscopically. Lingual tonsils were localized at the root of the tongue of camels of all ages in the form of several spherical macroscopic nodules protruding into the oropharynx. Each nodule possesses a single central crypt, covered with keratinized stratified squamous epithelium without any M cells and surrounded with an incomplete capsule. Each tonsillar crypt was lined with stratified squamous non-keratinized epithelium with lymphocytic infiltration forming patches of lymphoepithelium or reticular epithelium. Secondary lymphoid nodules extended under the apical epithelium. The interfollicular areas had diffused lymphocytes. Among these lymphocytes, high endothelial venules, macrophages, dendritic cells and plasma cells were observed. The organization of camel lingual tonsils in isolated units with separate crypts increases the surface area exposed to antigen. The present findings indicate a sustained immunological role of the lingual tonsils throughout the life of the one-humped camel.