Cerium-doped flower-shaped ZnO nano-crystallites as a sensing component for simultaneous electrochemical determination of epirubicin and methotrexate

A glassy carbon electrode (GCE) was modified with cerium-doped ZnO nanoflowers (Ce-ZnO/GCE) to obtain a sensor for direct simultaneous detection of the cancer drugs epirubicin and methotrexate. XRD, SEM and EDX techniques were used to characterize their morphology and structure. Electrochemical impe...

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Bibliographic Details
Published in:Mikrochimica acta (1966) 2020-01, Vol.187 (1), p.24-24, Article 24
Main Authors: Jandaghi, Nezhat, Jahani, Shohreh, Foroughi, Mohammad Mehdi, Kazemipour, Maryam, Ansari, Mehdi
Format: Article
Language:English
Subjects:
Analytical Chemistry
Cerium
Cerium - chemistry
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Electric properties
Electrochemistry - methods
Electrodes
Epirubicin - analysis
Epirubicin - blood
Epirubicin - chemistry
Epirubicin - urine
Humans
Hydrogen-Ion Concentration
Limit of Detection
Methotrexate
Methotrexate - analysis
Methotrexate - blood
Methotrexate - chemistry
Methotrexate - urine
Microengineering
Nanochemistry
Nanoparticles - chemistry
Nanotechnology
Original Paper
Sensors
Time Factors
Zinc oxide
Zinc Oxide - chemistry
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Summary:A glassy carbon electrode (GCE) was modified with cerium-doped ZnO nanoflowers (Ce-ZnO/GCE) to obtain a sensor for direct simultaneous detection of the cancer drugs epirubicin and methotrexate. XRD, SEM and EDX techniques were used to characterize their morphology and structure. Electrochemical impedance spectroscopy was applied to characterize the electrochemical features of the modified GCE. The experimental conditions were optimized. Diffusion coefficients and heterogeneous rate constants were determined for the oxidation of epirubicin. The differential pulse voltammetric response to epirubicin has a peak near 0.7 V (vs. Ag/AgCl at a scan rate of 50 mV s −1 ) and is linear in the 0.01 to 600 μM concentration range, and the detection limit is 2.3 nM (S/ N  = 5). The differential pulse voltammetric response to methotrexate has a peak near 0.75 V (vs. Ag/AgCl and the same scan rate) and is linear in the 0.01 to 500 μM concentration range, and the detection limit is 6.3 nM (S/ N  = 5). The method was applied to the simultaneous determination of epirubicin and methotrexate in pharmaceutical injections and in spiked diluted blood specimens. Graphical abstract Schematic of an electrochemical sensor based on Ce-doped ZnO nano-flowers modified glassy carbon electrode for detecting epirubicin
ISSN:0026-3672
1436-5073
DOI:10.1007/s00604-019-4016-2