Prognostic significance of FDG-PET/CT in determining upfront autologous stem cell transplantation for the treatment of peripheral T cell lymphomas

This observational study aimed to evaluate the prognostic significance of interim and final 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (PET/CT) responses to upfront autologous stem cell transplantation (ASCT) in patients with peripheral T cell lymphomas (PTCLs). A total...

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Bibliographic Details
Published in:Annals of hematology 2020, Vol.99 (1), p.83-91
Main Authors: Ahn, Seo-Yeon, Jung, Seung-Yeon, Jung, Sung-Hoon, Ahn, Jae-Sook, Lee, Je-Jung, Kim, Hyeoung-Joon, Kang, Sae-Ryung, Han, Yeon-Hee, Kwak, Jae-Yong, Yhim, Ho-Young, Yang, Deok-Hwan
Format: Article
Language:English
Subjects:
Adult
Autografts
Disease-Free Survival
Female
Fluorodeoxyglucose F18 - administration & dosage
Follow-Up Studies
Hematology
Hematopoietic Stem Cell Transplantation
Humans
Lymphoma
Lymphoma, T-Cell, Peripheral - diagnostic imaging
Lymphoma, T-Cell, Peripheral - mortality
Lymphoma, T-Cell, Peripheral - therapy
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Article
Positron Emission Tomography Computed Tomography
Retrospective Studies
Stem cell transplantation
Stem cells
Survival Rate
Tomography
Tomography, X-Ray Computed
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Summary:This observational study aimed to evaluate the prognostic significance of interim and final 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (PET/CT) responses to upfront autologous stem cell transplantation (ASCT) in patients with peripheral T cell lymphomas (PTCLs). A total of 118 patients, from two independent institutions, with newly diagnosed PTCLs were enrolled, and 96 of them were evaluated. PET/CT was assessed at diagnosis, and during and after the primary treatment. Clinical outcomes of interim and final PET/CT were compared between transplanted and non-transplanted patients. The responses of PET/CT were assessed based on visual analysis using the Deauville five-point scale (5-PS). Clinicopathological features of transplanted patients ( n  = 37) were similar to those of non-transplanted patients ( n  = 59). After a median follow-up of 60.8 months, only final PET/CT response based on 5-PS was the independent prognostic factor of survival outcome ( P  
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-019-03867-9