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Prognostic significance of FDG-PET/CT in determining upfront autologous stem cell transplantation for the treatment of peripheral T cell lymphomas
This observational study aimed to evaluate the prognostic significance of interim and final 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (PET/CT) responses to upfront autologous stem cell transplantation (ASCT) in patients with peripheral T cell lymphomas (PTCLs). A total...
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| Published in: | Annals of hematology 2020, Vol.99 (1), p.83-91 |
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| creator | Ahn, Seo-Yeon Jung, Seung-Yeon Jung, Sung-Hoon Ahn, Jae-Sook Lee, Je-Jung Kim, Hyeoung-Joon Kang, Sae-Ryung Han, Yeon-Hee Kwak, Jae-Yong Yhim, Ho-Young Yang, Deok-Hwan |
| description | This observational study aimed to evaluate the prognostic significance of interim and final
18
F-fluorodeoxyglucose positron emission tomography-computed tomography (PET/CT) responses to upfront autologous stem cell transplantation (ASCT) in patients with peripheral T cell lymphomas (PTCLs). A total of 118 patients, from two independent institutions, with newly diagnosed PTCLs were enrolled, and 96 of them were evaluated. PET/CT was assessed at diagnosis, and during and after the primary treatment. Clinical outcomes of interim and final PET/CT were compared between transplanted and non-transplanted patients. The responses of PET/CT were assessed based on visual analysis using the Deauville five-point scale (5-PS). Clinicopathological features of transplanted patients (
n
= 37) were similar to those of non-transplanted patients (
n
= 59). After a median follow-up of 60.8 months, only final PET/CT response based on 5-PS was the independent prognostic factor of survival outcome (
P
|
| doi_str_mv | 10.1007/s00277-019-03867-9 |
| format | article |
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18
F-fluorodeoxyglucose positron emission tomography-computed tomography (PET/CT) responses to upfront autologous stem cell transplantation (ASCT) in patients with peripheral T cell lymphomas (PTCLs). A total of 118 patients, from two independent institutions, with newly diagnosed PTCLs were enrolled, and 96 of them were evaluated. PET/CT was assessed at diagnosis, and during and after the primary treatment. Clinical outcomes of interim and final PET/CT were compared between transplanted and non-transplanted patients. The responses of PET/CT were assessed based on visual analysis using the Deauville five-point scale (5-PS). Clinicopathological features of transplanted patients (
n
= 37) were similar to those of non-transplanted patients (
n
= 59). After a median follow-up of 60.8 months, only final PET/CT response based on 5-PS was the independent prognostic factor of survival outcome (
P
< 0.001; HR 8.215; 95% C.I. 2.97–22.72) in multivariate analysis. Interim PET/CT response did not have a differential potential for predicting progression-free survival (PFS). In 59 patients, with score 1 or 2 in final PET/CT, the PFS rate was not significantly different between transplanted and non-transplanted patients (
P
= 0.970). Moreover, among the 37 patients with final PET/CT response score of 3–4, the PFS rate was equally poor in both transplanted and non-transplanted patients (
P
= 0.178). Final PET/CT assessment, based on 5-PS, was an important prognostic parameter for primary treatment of PTCLs, regardless of upfront ASCT. Interim PET/CT response could not be an indicator to determine the requirement for upfront ASCT.</description><identifier>ISSN: 0939-5555</identifier><identifier>EISSN: 1432-0584</identifier><identifier>DOI: 10.1007/s00277-019-03867-9</identifier><identifier>PMID: 31807859</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Autografts ; Disease-Free Survival ; Female ; Fluorodeoxyglucose F18 - administration & dosage ; Follow-Up Studies ; Hematology ; Hematopoietic Stem Cell Transplantation ; Humans ; Lymphoma ; Lymphoma, T-Cell, Peripheral - diagnostic imaging ; Lymphoma, T-Cell, Peripheral - mortality ; Lymphoma, T-Cell, Peripheral - therapy ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Article ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Stem cell transplantation ; Stem cells ; Survival Rate ; Tomography ; Tomography, X-Ray Computed</subject><ispartof>Annals of hematology, 2020, Vol.99 (1), p.83-91</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Annals of Hematology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-d3504863f1f7f08b8e83534bf1bb0348b567d47ae01aac3b1a9852dc78d550053</citedby><cites>FETCH-LOGICAL-c375t-d3504863f1f7f08b8e83534bf1bb0348b567d47ae01aac3b1a9852dc78d550053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31807859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahn, Seo-Yeon</creatorcontrib><creatorcontrib>Jung, Seung-Yeon</creatorcontrib><creatorcontrib>Jung, Sung-Hoon</creatorcontrib><creatorcontrib>Ahn, Jae-Sook</creatorcontrib><creatorcontrib>Lee, Je-Jung</creatorcontrib><creatorcontrib>Kim, Hyeoung-Joon</creatorcontrib><creatorcontrib>Kang, Sae-Ryung</creatorcontrib><creatorcontrib>Han, Yeon-Hee</creatorcontrib><creatorcontrib>Kwak, Jae-Yong</creatorcontrib><creatorcontrib>Yhim, Ho-Young</creatorcontrib><creatorcontrib>Yang, Deok-Hwan</creatorcontrib><title>Prognostic significance of FDG-PET/CT in determining upfront autologous stem cell transplantation for the treatment of peripheral T cell lymphomas</title><title>Annals of hematology</title><addtitle>Ann Hematol</addtitle><addtitle>Ann Hematol</addtitle><description>This observational study aimed to evaluate the prognostic significance of interim and final
18
F-fluorodeoxyglucose positron emission tomography-computed tomography (PET/CT) responses to upfront autologous stem cell transplantation (ASCT) in patients with peripheral T cell lymphomas (PTCLs). A total of 118 patients, from two independent institutions, with newly diagnosed PTCLs were enrolled, and 96 of them were evaluated. PET/CT was assessed at diagnosis, and during and after the primary treatment. Clinical outcomes of interim and final PET/CT were compared between transplanted and non-transplanted patients. The responses of PET/CT were assessed based on visual analysis using the Deauville five-point scale (5-PS). Clinicopathological features of transplanted patients (
n
= 37) were similar to those of non-transplanted patients (
n
= 59). After a median follow-up of 60.8 months, only final PET/CT response based on 5-PS was the independent prognostic factor of survival outcome (
P
< 0.001; HR 8.215; 95% C.I. 2.97–22.72) in multivariate analysis. Interim PET/CT response did not have a differential potential for predicting progression-free survival (PFS). In 59 patients, with score 1 or 2 in final PET/CT, the PFS rate was not significantly different between transplanted and non-transplanted patients (
P
= 0.970). Moreover, among the 37 patients with final PET/CT response score of 3–4, the PFS rate was equally poor in both transplanted and non-transplanted patients (
P
= 0.178). Final PET/CT assessment, based on 5-PS, was an important prognostic parameter for primary treatment of PTCLs, regardless of upfront ASCT. Interim PET/CT response could not be an indicator to determine the requirement for upfront ASCT.</description><subject>Adult</subject><subject>Autografts</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18 - administration & dosage</subject><subject>Follow-Up Studies</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Humans</subject><subject>Lymphoma</subject><subject>Lymphoma, T-Cell, Peripheral - diagnostic imaging</subject><subject>Lymphoma, T-Cell, Peripheral - mortality</subject><subject>Lymphoma, T-Cell, Peripheral - therapy</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Retrospective Studies</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Survival Rate</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed</subject><issn>0939-5555</issn><issn>1432-0584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kcFuFSEUhonR2Gv1BVwYEjdusAcYLszSXNtq0sQurmvCzMBcmhkYgVn0NfrEUqdq4kI2JPD9P4d8CL2l8JECyIsMwKQkQFsCXO0laZ-hHW04IyBU8xztoOUtEXWdoVc53wFQphr2Ep1xqkAq0e7Qw22KY4i5-B5nPwbvfG9Cb3F0-OrzNbm9PF4cjtgHPNhi0-yDDyNeF5diKNisJU5xjGvGudgZ93aacEkm5GUyoZjiY8AuJlxOtp5bU2ZbY7V7sckvJ5vMhI9bbLqfl1OcTX6NXjgzZfvmaT9H368uj4cv5Obb9dfDpxvScykKGbiARu25o046UJ2yigvedI52HfBGdWIvh0YaC9SYnnfUtEqwoZdqEAJA8HP0YetdUvyx2lz07PPjKCbY-iPNOGOyaZjgFX3_D3oX1xTqdJXiXHGmqKoU26g-xZyTdXpJfjbpXlPQj8b0ZkxXY_qXMd3W0Lun6rWb7fAn8ltRBfgG5HoVRpv-vv2f2p-_AqK9</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Ahn, Seo-Yeon</creator><creator>Jung, Seung-Yeon</creator><creator>Jung, Sung-Hoon</creator><creator>Ahn, Jae-Sook</creator><creator>Lee, Je-Jung</creator><creator>Kim, Hyeoung-Joon</creator><creator>Kang, Sae-Ryung</creator><creator>Han, Yeon-Hee</creator><creator>Kwak, Jae-Yong</creator><creator>Yhim, Ho-Young</creator><creator>Yang, Deok-Hwan</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2020</creationdate><title>Prognostic significance of FDG-PET/CT in determining upfront autologous stem cell transplantation for the treatment of peripheral T cell lymphomas</title><author>Ahn, Seo-Yeon ; Jung, Seung-Yeon ; Jung, Sung-Hoon ; Ahn, Jae-Sook ; Lee, Je-Jung ; Kim, Hyeoung-Joon ; Kang, Sae-Ryung ; Han, Yeon-Hee ; Kwak, Jae-Yong ; Yhim, Ho-Young ; Yang, Deok-Hwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-d3504863f1f7f08b8e83534bf1bb0348b567d47ae01aac3b1a9852dc78d550053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Autografts</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18 - administration & dosage</topic><topic>Follow-Up Studies</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Humans</topic><topic>Lymphoma</topic><topic>Lymphoma, T-Cell, Peripheral - diagnostic imaging</topic><topic>Lymphoma, T-Cell, Peripheral - mortality</topic><topic>Lymphoma, T-Cell, Peripheral - therapy</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Retrospective Studies</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Survival Rate</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahn, Seo-Yeon</creatorcontrib><creatorcontrib>Jung, Seung-Yeon</creatorcontrib><creatorcontrib>Jung, Sung-Hoon</creatorcontrib><creatorcontrib>Ahn, Jae-Sook</creatorcontrib><creatorcontrib>Lee, Je-Jung</creatorcontrib><creatorcontrib>Kim, Hyeoung-Joon</creatorcontrib><creatorcontrib>Kang, Sae-Ryung</creatorcontrib><creatorcontrib>Han, Yeon-Hee</creatorcontrib><creatorcontrib>Kwak, Jae-Yong</creatorcontrib><creatorcontrib>Yhim, Ho-Young</creatorcontrib><creatorcontrib>Yang, Deok-Hwan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection (ProQuest Medical & Health Databases)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahn, Seo-Yeon</au><au>Jung, Seung-Yeon</au><au>Jung, Sung-Hoon</au><au>Ahn, Jae-Sook</au><au>Lee, Je-Jung</au><au>Kim, Hyeoung-Joon</au><au>Kang, Sae-Ryung</au><au>Han, Yeon-Hee</au><au>Kwak, Jae-Yong</au><au>Yhim, Ho-Young</au><au>Yang, Deok-Hwan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of FDG-PET/CT in determining upfront autologous stem cell transplantation for the treatment of peripheral T cell lymphomas</atitle><jtitle>Annals of hematology</jtitle><stitle>Ann Hematol</stitle><addtitle>Ann Hematol</addtitle><date>2020</date><risdate>2020</risdate><volume>99</volume><issue>1</issue><spage>83</spage><epage>91</epage><pages>83-91</pages><issn>0939-5555</issn><eissn>1432-0584</eissn><abstract>This observational study aimed to evaluate the prognostic significance of interim and final
18
F-fluorodeoxyglucose positron emission tomography-computed tomography (PET/CT) responses to upfront autologous stem cell transplantation (ASCT) in patients with peripheral T cell lymphomas (PTCLs). A total of 118 patients, from two independent institutions, with newly diagnosed PTCLs were enrolled, and 96 of them were evaluated. PET/CT was assessed at diagnosis, and during and after the primary treatment. Clinical outcomes of interim and final PET/CT were compared between transplanted and non-transplanted patients. The responses of PET/CT were assessed based on visual analysis using the Deauville five-point scale (5-PS). Clinicopathological features of transplanted patients (
n
= 37) were similar to those of non-transplanted patients (
n
= 59). After a median follow-up of 60.8 months, only final PET/CT response based on 5-PS was the independent prognostic factor of survival outcome (
P
< 0.001; HR 8.215; 95% C.I. 2.97–22.72) in multivariate analysis. Interim PET/CT response did not have a differential potential for predicting progression-free survival (PFS). In 59 patients, with score 1 or 2 in final PET/CT, the PFS rate was not significantly different between transplanted and non-transplanted patients (
P
= 0.970). Moreover, among the 37 patients with final PET/CT response score of 3–4, the PFS rate was equally poor in both transplanted and non-transplanted patients (
P
= 0.178). Final PET/CT assessment, based on 5-PS, was an important prognostic parameter for primary treatment of PTCLs, regardless of upfront ASCT. Interim PET/CT response could not be an indicator to determine the requirement for upfront ASCT.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31807859</pmid><doi>10.1007/s00277-019-03867-9</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Autografts Disease-Free Survival Female Fluorodeoxyglucose F18 - administration & dosage Follow-Up Studies Hematology Hematopoietic Stem Cell Transplantation Humans Lymphoma Lymphoma, T-Cell, Peripheral - diagnostic imaging Lymphoma, T-Cell, Peripheral - mortality Lymphoma, T-Cell, Peripheral - therapy Male Medical prognosis Medicine Medicine & Public Health Middle Aged Oncology Original Article Positron Emission Tomography Computed Tomography Retrospective Studies Stem cell transplantation Stem cells Survival Rate Tomography Tomography, X-Ray Computed |
| title | Prognostic significance of FDG-PET/CT in determining upfront autologous stem cell transplantation for the treatment of peripheral T cell lymphomas |
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