Anti-inflammatory, anti-pyretic and analgesic activities of Tamarix dioica

• Published in: Pakistan journal of pharmaceutical sciences 2019-09, Vol.32 (5), p.2083-2089
• Main Authors: Iqbal, Arshad, Din, Siraj Ud, Bakht, Jehan, Khan, Inam Ullah, Shah, Zamarud
• Format: Article
• Language: English
• Subjects: Acetic Acid - pharmacology; Analgesics; Analgesics - chemistry; Analgesics - pharmacology; Animals; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Anti-inflammatory agents; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Antifungal agents; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Antipyretics - chemistry; Antipyretics - pharmacology; Carrageenan; Cosmetics industry; Disease Models, Animal; Diuretics; Edema; Edema - drug therapy; Edema - microbiology; Female; Herbal medicine; Inflammation - drug therapy; Liver - drug effects; Male; Methanol - chemistry; Phytotherapy - methods; Plant Extracts - chemistry; Plant Extracts - pharmacology; Spleen - drug effects; Tamaricaceae - chemistry
• ISSN: 1011-601X

Medicinal and aromatic plants contribute to major portion of the flora. The plant materials obtained from these plants are used in the pharmaceuticals, cosmetics, and drug industries. Tamarix dioica is locally used in the management of splenic and hepatic inflammation as well as diuretic and carminative. It also possesses cytotoxic, antimicrobial, antifungal and anti-inflammatory activity. The present study investigates the anti-inflammatory, anti-pyretic and analgesic activities of the crude methanolic extract from Tamarix dioica. Anti-inflammatory activity was measured by Carrageenan Induced Paw Edema and Xylene Induced Ear Edema methods. Pyrexia induction with Brewer's yeast assay was used to determine antipyretic activity and analgesic activity was estimated by acetic acid induced writhing and hot plate methods. The data indicated that anti-inflammatory, anti-pyretic and analgesic activities of the crude methanolic extract from Tamarix dioica was dose and time dependent when measured by different assays. Exposure of model animal to increasing concentrations of the plant extract for longer period increased their anti-inflammatory, anti-pyretic and analgesic activities. Significantly highest anti-inflammatory, anti-pyretic and analgesic activities were noted at highest doses of the crude methanolic extract for longer exposure compared with their respective controls.