Loading…

Difference in the prevalence of subclinical left ventricular impairment among left ventricular geometric pattern in a community-based population

•Left ventricular (LV) diastolic dysfunction was more frequently observed in subjects with LV hypertrophy.•LV mass, not relative wall thickness, was a determinant of LV diastolic dysfunction.•Ten percent of subjects with normal LV geometry had LV diastolic dysfunction.•Clinical impact of subclinical...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiology 2020-04, Vol.75 (4), p.439-446
Main Authors: Hasegawa, Takuya, Asakura, Masanori, Asanuma, Hiroshi, Amaki, Makoto, Takahama, Hiroyuki, Sugano, Yasuo, Kanzaki, Hideaki, Yasuda, Satoshi, Anzai, Toshihisa, Izumi, Chisato, Kitakaze, Masafumi
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Left ventricular (LV) diastolic dysfunction was more frequently observed in subjects with LV hypertrophy.•LV mass, not relative wall thickness, was a determinant of LV diastolic dysfunction.•Ten percent of subjects with normal LV geometry had LV diastolic dysfunction.•Clinical impact of subclinical LV diastolic dysfunction should be elucidated. Left ventricular (LV) hypertrophy is reported to cause LV diastolic dysfunction. This study aimed to examine the prevalence of LV diastolic dysfunction in each group categorized by the geometric pattern of LV hypertrophy in a community-based population. We studied 1260 community-dwelling subjects who experienced no symptoms of obvious heart disease (461 men, 799 women) and who participated in annual health check-ups in a rural Japanese community. The subjects were divided into 4 groups according to LV mass index and relative wall thickness: normal geometry, concentric remodeling, eccentric hypertrophy, and concentric hypertrophy. We investigated the prevalence of LV diastolic dysfunction in the overall and stratified population by LV geometric pattern. LV diastolic function was determined by 3 echocardiographic parameters of LV diastolic function: early diastolic myocardial velocity, the ratio of early diastolic mitral inflow velocity and myocardial velocity, and indexed left atrial dimension. LV diastolic dysfunction was defined as the presence of abnormal values in more than 2 of 3 echocardiographic parameters. The prevalence of LV diastolic dysfunction was higher in the categories with more severe LV hypertrophy. However, LV mass index, rather than relative wall thickness, was a significant determinant of LV diastolic dysfunction, after adjustment for comorbidities. In addition, 71 (10%) out of 740 subjects with normal LV geometric pattern had LV diastolic dysfunction even without obvious LV geometric change. The prevalence of LV diastolic dysfunction was higher in the subjects with more severe LV hypertrophy in a community-based population. Subclinical LV diastolic dysfunction without obvious LV geometric change should be noted and its clinical impact should be elucidated.
ISSN:0914-5087
1876-4738
DOI:10.1016/j.jjcc.2019.09.007