Serum uric acid and left ventricular geometry pattern in obese children

Relative importance of traditional and non-traditional components of metabolic syndrome (MetSy) as risk factors for subclinical target organ damage in obese children is still under investigation. Recent studies highlight the role of serum uric acid (SUA) as an emerging non-traditional independent ri...

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Published in:Atherosclerosis. Supplements 2019-12, Vol.40, p.88-93
Main Authors: Bjelakovic, Bojko, Stefanutti, Claudia, Bonic, Dejan, Vukovic, Vladimir, Kavaric, Nebojsa, Saranac, Ljiljana, Kocic, Gordana, Klisic, Aleksandra, Jevtović Stojmenov, Tatjana, Lukic, Stevo, Jovic, Marko, Bjelakovic, Milica
Format: Article
Language:English
Subjects:
Adolescent
Case-Control Studies
Child
Cross-Sectional Studies
Female
Humans
Hypertrophy, Left Ventricular - blood
Hypertrophy, Left Ventricular - etiology
Left ventricular mass index
Male
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - complications
Obese children
Pediatric Obesity - blood
Pediatric Obesity - complications
Relative wall thickness
Risk Factors
Serum uric acid
Uric Acid - blood
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Summary:Relative importance of traditional and non-traditional components of metabolic syndrome (MetSy) as risk factors for subclinical target organ damage in obese children is still under investigation. Recent studies highlight the role of serum uric acid (SUA) as an emerging non-traditional independent risk factor which correlates with obesity, MetSy, type 2 diabetes, preclinical cardiac and extracardiac organ damage, as well as cardiovascular events. To study the relationship between SUA and left ventricular geometry pattern in obese children with or without MetSy. In this cross-sectional study, a total of 73 obese children, 64.4% male, and 35.6% female, with median age of 15 years (IQR = 12–16) were examined. Body mass index, glycaemia, standard lipid profile, fasting insulin level, HOMA index, serum uric acid level, 24-h average systolic blood pressure, left ventricular mass index (LVMI) and relative wall thickness (RWT) were evaluated in all children. LVMI in our study group was 46 g/m2.7 (IQR = 42–55) while the RWT was 37% (IQR = 31–41). Median SUA level was 341 μmol/L (IQR = 283–387). In the entire sample of children, SUA was independently associated with the RWT (coeff = 0.02, p 
ISSN:1567-5688
1878-5050
DOI:10.1016/j.atherosclerosissup.2019.08.035