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Serum uric acid and left ventricular geometry pattern in obese children
Relative importance of traditional and non-traditional components of metabolic syndrome (MetSy) as risk factors for subclinical target organ damage in obese children is still under investigation. Recent studies highlight the role of serum uric acid (SUA) as an emerging non-traditional independent ri...
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| Published in: | Atherosclerosis. Supplements 2019-12, Vol.40, p.88-93 |
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| container_title | Atherosclerosis. Supplements |
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| creator | Bjelakovic, Bojko Stefanutti, Claudia Bonic, Dejan Vukovic, Vladimir Kavaric, Nebojsa Saranac, Ljiljana Kocic, Gordana Klisic, Aleksandra Jevtović Stojmenov, Tatjana Lukic, Stevo Jovic, Marko Bjelakovic, Milica |
| description | Relative importance of traditional and non-traditional components of metabolic syndrome (MetSy) as risk factors for subclinical target organ damage in obese children is still under investigation. Recent studies highlight the role of serum uric acid (SUA) as an emerging non-traditional independent risk factor which correlates with obesity, MetSy, type 2 diabetes, preclinical cardiac and extracardiac organ damage, as well as cardiovascular events.
To study the relationship between SUA and left ventricular geometry pattern in obese children with or without MetSy.
In this cross-sectional study, a total of 73 obese children, 64.4% male, and 35.6% female, with median age of 15 years (IQR = 12–16) were examined. Body mass index, glycaemia, standard lipid profile, fasting insulin level, HOMA index, serum uric acid level, 24-h average systolic blood pressure, left ventricular mass index (LVMI) and relative wall thickness (RWT) were evaluated in all children.
LVMI in our study group was 46 g/m2.7 (IQR = 42–55) while the RWT was 37% (IQR = 31–41). Median SUA level was 341 μmol/L (IQR = 283–387). In the entire sample of children, SUA was independently associated with the RWT (coeff = 0.02, p |
| doi_str_mv | 10.1016/j.atherosclerosissup.2019.08.035 |
| format | article |
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To study the relationship between SUA and left ventricular geometry pattern in obese children with or without MetSy.
In this cross-sectional study, a total of 73 obese children, 64.4% male, and 35.6% female, with median age of 15 years (IQR = 12–16) were examined. Body mass index, glycaemia, standard lipid profile, fasting insulin level, HOMA index, serum uric acid level, 24-h average systolic blood pressure, left ventricular mass index (LVMI) and relative wall thickness (RWT) were evaluated in all children.
LVMI in our study group was 46 g/m2.7 (IQR = 42–55) while the RWT was 37% (IQR = 31–41). Median SUA level was 341 μmol/L (IQR = 283–387). In the entire sample of children, SUA was independently associated with the RWT (coeff = 0.02, p < 0.01). In a sub-group of metabolically unhealthy children, we found no statistically significant association between SUA and LVMI nor between SUA and RWT (coeff. = 0.002, p = 0.92; coeff. = 0.01, p = 0.20, respectively).
Serum uric acid is an important independent non-traditional risk factor for the development of concentric left ventricular geometry in obese children. These findings deserve further investigation to determine whether high SUA in obese children may be a therapeutic target.</description><identifier>ISSN: 1567-5688</identifier><identifier>EISSN: 1878-5050</identifier><identifier>DOI: 10.1016/j.atherosclerosissup.2019.08.035</identifier><identifier>PMID: 31818454</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Case-Control Studies ; Child ; Cross-Sectional Studies ; Female ; Humans ; Hypertrophy, Left Ventricular - blood ; Hypertrophy, Left Ventricular - etiology ; Left ventricular mass index ; Male ; Metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - complications ; Obese children ; Pediatric Obesity - blood ; Pediatric Obesity - complications ; Relative wall thickness ; Risk Factors ; Serum uric acid ; Uric Acid - blood</subject><ispartof>Atherosclerosis. Supplements, 2019-12, Vol.40, p.88-93</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-5afa5b1c74b6b7e29f16274ce44af5d04c878b21bf4f90ad9b6f3d8c6b1cc43d3</citedby><cites>FETCH-LOGICAL-c468t-5afa5b1c74b6b7e29f16274ce44af5d04c878b21bf4f90ad9b6f3d8c6b1cc43d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31818454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bjelakovic, Bojko</creatorcontrib><creatorcontrib>Stefanutti, Claudia</creatorcontrib><creatorcontrib>Bonic, Dejan</creatorcontrib><creatorcontrib>Vukovic, Vladimir</creatorcontrib><creatorcontrib>Kavaric, Nebojsa</creatorcontrib><creatorcontrib>Saranac, Ljiljana</creatorcontrib><creatorcontrib>Kocic, Gordana</creatorcontrib><creatorcontrib>Klisic, Aleksandra</creatorcontrib><creatorcontrib>Jevtović Stojmenov, Tatjana</creatorcontrib><creatorcontrib>Lukic, Stevo</creatorcontrib><creatorcontrib>Jovic, Marko</creatorcontrib><creatorcontrib>Bjelakovic, Milica</creatorcontrib><title>Serum uric acid and left ventricular geometry pattern in obese children</title><title>Atherosclerosis. Supplements</title><addtitle>Atheroscler Suppl</addtitle><description>Relative importance of traditional and non-traditional components of metabolic syndrome (MetSy) as risk factors for subclinical target organ damage in obese children is still under investigation. Recent studies highlight the role of serum uric acid (SUA) as an emerging non-traditional independent risk factor which correlates with obesity, MetSy, type 2 diabetes, preclinical cardiac and extracardiac organ damage, as well as cardiovascular events.
To study the relationship between SUA and left ventricular geometry pattern in obese children with or without MetSy.
In this cross-sectional study, a total of 73 obese children, 64.4% male, and 35.6% female, with median age of 15 years (IQR = 12–16) were examined. Body mass index, glycaemia, standard lipid profile, fasting insulin level, HOMA index, serum uric acid level, 24-h average systolic blood pressure, left ventricular mass index (LVMI) and relative wall thickness (RWT) were evaluated in all children.
LVMI in our study group was 46 g/m2.7 (IQR = 42–55) while the RWT was 37% (IQR = 31–41). Median SUA level was 341 μmol/L (IQR = 283–387). In the entire sample of children, SUA was independently associated with the RWT (coeff = 0.02, p < 0.01). In a sub-group of metabolically unhealthy children, we found no statistically significant association between SUA and LVMI nor between SUA and RWT (coeff. = 0.002, p = 0.92; coeff. = 0.01, p = 0.20, respectively).
Serum uric acid is an important independent non-traditional risk factor for the development of concentric left ventricular geometry in obese children. These findings deserve further investigation to determine whether high SUA in obese children may be a therapeutic target.</description><subject>Adolescent</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertrophy, Left Ventricular - blood</subject><subject>Hypertrophy, Left Ventricular - etiology</subject><subject>Left ventricular mass index</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - complications</subject><subject>Obese children</subject><subject>Pediatric Obesity - blood</subject><subject>Pediatric Obesity - complications</subject><subject>Relative wall thickness</subject><subject>Risk Factors</subject><subject>Serum uric acid</subject><subject>Uric Acid - blood</subject><issn>1567-5688</issn><issn>1878-5050</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqNkE1PwzAMhiMEYjD4CyjHXVqSNmnTG2jiU5M4AOcoTRyWqR8jSZH492QacOHCxbas16_tB6EFJTkltLrc5CquwY9Bd7voQpi2eUFokxORk5IfoBMqapFxwslhqnlVZ7wSYoZOQ9gQQiht-DGalVRQwTg7QXfP4KceT95prLQzWA0Gd2Aj_oAhpu7UKY_fYOwh-k-8VTGCH7Ab8NhCAKzXrjMehjN0ZFUX4Pw7z9Hr7c3L8j5bPd09LK9XmWaViBlXVvGW6pq1VVtD0VhaFTXTwJiy3BCm0_ltQVvLbEOUadrKlkboKs1oVppyjhZ7360f3ycIUfYuaOg6NcA4BVmURclqWpd1kl7tpTqhCh6s3HrXK_8pKZE7nHIj_-KUO5ySCJlwJouL721T24P5NfjhlwSPewGknz8ceBm0g0GDcR50lGZ0_9_2BU4tlLs</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Bjelakovic, Bojko</creator><creator>Stefanutti, Claudia</creator><creator>Bonic, Dejan</creator><creator>Vukovic, Vladimir</creator><creator>Kavaric, Nebojsa</creator><creator>Saranac, Ljiljana</creator><creator>Kocic, Gordana</creator><creator>Klisic, Aleksandra</creator><creator>Jevtović Stojmenov, Tatjana</creator><creator>Lukic, Stevo</creator><creator>Jovic, Marko</creator><creator>Bjelakovic, Milica</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20191201</creationdate><title>Serum uric acid and left ventricular geometry pattern in obese children</title><author>Bjelakovic, Bojko ; Stefanutti, Claudia ; Bonic, Dejan ; Vukovic, Vladimir ; Kavaric, Nebojsa ; Saranac, Ljiljana ; Kocic, Gordana ; Klisic, Aleksandra ; Jevtović Stojmenov, Tatjana ; Lukic, Stevo ; Jovic, Marko ; Bjelakovic, Milica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-5afa5b1c74b6b7e29f16274ce44af5d04c878b21bf4f90ad9b6f3d8c6b1cc43d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertrophy, Left Ventricular - blood</topic><topic>Hypertrophy, Left Ventricular - etiology</topic><topic>Left ventricular mass index</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - complications</topic><topic>Obese children</topic><topic>Pediatric Obesity - blood</topic><topic>Pediatric Obesity - complications</topic><topic>Relative wall thickness</topic><topic>Risk Factors</topic><topic>Serum uric acid</topic><topic>Uric Acid - blood</topic><toplevel>online_resources</toplevel><creatorcontrib>Bjelakovic, Bojko</creatorcontrib><creatorcontrib>Stefanutti, Claudia</creatorcontrib><creatorcontrib>Bonic, Dejan</creatorcontrib><creatorcontrib>Vukovic, Vladimir</creatorcontrib><creatorcontrib>Kavaric, Nebojsa</creatorcontrib><creatorcontrib>Saranac, Ljiljana</creatorcontrib><creatorcontrib>Kocic, Gordana</creatorcontrib><creatorcontrib>Klisic, Aleksandra</creatorcontrib><creatorcontrib>Jevtović Stojmenov, Tatjana</creatorcontrib><creatorcontrib>Lukic, Stevo</creatorcontrib><creatorcontrib>Jovic, Marko</creatorcontrib><creatorcontrib>Bjelakovic, Milica</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis. Supplements</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bjelakovic, Bojko</au><au>Stefanutti, Claudia</au><au>Bonic, Dejan</au><au>Vukovic, Vladimir</au><au>Kavaric, Nebojsa</au><au>Saranac, Ljiljana</au><au>Kocic, Gordana</au><au>Klisic, Aleksandra</au><au>Jevtović Stojmenov, Tatjana</au><au>Lukic, Stevo</au><au>Jovic, Marko</au><au>Bjelakovic, Milica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum uric acid and left ventricular geometry pattern in obese children</atitle><jtitle>Atherosclerosis. Supplements</jtitle><addtitle>Atheroscler Suppl</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>40</volume><spage>88</spage><epage>93</epage><pages>88-93</pages><issn>1567-5688</issn><eissn>1878-5050</eissn><abstract>Relative importance of traditional and non-traditional components of metabolic syndrome (MetSy) as risk factors for subclinical target organ damage in obese children is still under investigation. Recent studies highlight the role of serum uric acid (SUA) as an emerging non-traditional independent risk factor which correlates with obesity, MetSy, type 2 diabetes, preclinical cardiac and extracardiac organ damage, as well as cardiovascular events.
To study the relationship between SUA and left ventricular geometry pattern in obese children with or without MetSy.
In this cross-sectional study, a total of 73 obese children, 64.4% male, and 35.6% female, with median age of 15 years (IQR = 12–16) were examined. Body mass index, glycaemia, standard lipid profile, fasting insulin level, HOMA index, serum uric acid level, 24-h average systolic blood pressure, left ventricular mass index (LVMI) and relative wall thickness (RWT) were evaluated in all children.
LVMI in our study group was 46 g/m2.7 (IQR = 42–55) while the RWT was 37% (IQR = 31–41). Median SUA level was 341 μmol/L (IQR = 283–387). In the entire sample of children, SUA was independently associated with the RWT (coeff = 0.02, p < 0.01). In a sub-group of metabolically unhealthy children, we found no statistically significant association between SUA and LVMI nor between SUA and RWT (coeff. = 0.002, p = 0.92; coeff. = 0.01, p = 0.20, respectively).
Serum uric acid is an important independent non-traditional risk factor for the development of concentric left ventricular geometry in obese children. These findings deserve further investigation to determine whether high SUA in obese children may be a therapeutic target.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31818454</pmid><doi>10.1016/j.atherosclerosissup.2019.08.035</doi><tpages>6</tpages></addata></record> |
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| ispartof | Atherosclerosis. Supplements, 2019-12, Vol.40, p.88-93 |
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| source | ScienceDirect Journals |
| subjects | Adolescent Case-Control Studies Child Cross-Sectional Studies Female Humans Hypertrophy, Left Ventricular - blood Hypertrophy, Left Ventricular - etiology Left ventricular mass index Male Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - complications Obese children Pediatric Obesity - blood Pediatric Obesity - complications Relative wall thickness Risk Factors Serum uric acid Uric Acid - blood |
| title | Serum uric acid and left ventricular geometry pattern in obese children |
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