Quinazoline-Containing Indole Alkaloids from the Marine-Derived Fungus Aspergillus sp. HNMF114

Seven new quinazoline-containing indole alkaloids (1–7) named aspertoryadins A–G, along with nine known ones (8–16), were isolated from the marine-derived fungus Aspergillus sp. HNMF114 from the bivalve mollusk Sanguinolaria chinensis. The structures of the new compounds were elucidated from spectro...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2019-12, Vol.82 (12), p.3456-3463
Main Authors: Kong, Fan-Dong, Zhang, Sheng-Liang, Zhou, Shuang-Qing, Ma, Qing-Yun, Xie, Qing-Yi, Chen, Jin-Ping, Li, Jiu-Hui, Zhou, Li-Man, Yuan, Jing-Zhe, Hu, Zhong, Dai, Hao-Fu, Huang, Xiao-Long, Zhao, You-Xing
Format: Article
Language:English
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Summary:Seven new quinazoline-containing indole alkaloids (1–7) named aspertoryadins A–G, along with nine known ones (8–16), were isolated from the marine-derived fungus Aspergillus sp. HNMF114 from the bivalve mollusk Sanguinolaria chinensis. The structures of the new compounds were elucidated from spectroscopic data, X-ray diffraction analysis, ECD spectra analysis, and ECD calculations. Compound 1 bears an aminosulfonyl group in the structure, which is rarely encountered in natural products. Compounds 6, 7, and 13 exhibited quorum sensing inhibitory activity against Chromobacterium violaceum CV026 with MIC values of 32, 32, and 16 μg/well, respectively.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.9b00845