Autophagy-regulating N-heterocycles derivatives as potential anticancer agents

As a double-edged sword, autophagy in cancer cells could either suppress or promote tumorigenesis. Nowadays, more and more natural compounds with autophagy-regulating activities exhibit therapeutic effects against various cancers. N-Heterocycle derivatives plays an important role for discovery new d...

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Published in:Future medicinal chemistry 2020-02, Vol.12 (3), p.223-242
Main Authors: Liang, Xiaoxia, Zhang, Li, Li, Fanglong, Luan, Shangxian, He, Changliang, Yin, Lizi, Yin, Zhongqiong, Zou, Yuanfeng, Yue, Guizhou, Li, Lixia, Song, Xu, Lv, Cheng, Zhang, Wei, Jing, Bo
Format: Article
Language:English
Subjects:
anticancer drugs
Antitumor agents
Apoptosis
Autophagy
autophagy-regulating
Breast cancer
Cytotoxicity
Diabetes
Drug development
Drug discovery
Microscopy
N-heterocycles derivatives
Pancreatic cancer
Phagocytosis
Piperine
Prostate cancer
Tumorigenesis
Tumors
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Summary:As a double-edged sword, autophagy in cancer cells could either suppress or promote tumorigenesis. Nowadays, more and more natural compounds with autophagy-regulating activities exhibit therapeutic effects against various cancers. N-Heterocycle derivatives plays an important role for discovery new drugs. In this review, we summarize and classify 116 N-heterocycle derivatives with autophagy-regulating activities in the past decade into 12 classes according to structure characteristics. The structural features, bioactivities, mechanism and problems faced in this field are discussed and reported for the first time. Some of these even exhibited outstanding antitumor activities, including bisaminoquinoline ( ), pancratistatin ( ), 10-hydroxyevodiamine ( ), lycorine ( ), piperine ( ) and iridium (III) complex ( ), which are potential drug candidates for antitumor therapy.
ISSN:1756-8919
1756-8927
DOI:10.4155/fmc-2019-0294