Non-alcoholic fatty liver diseases: from role of gut microbiota to microbial-based therapies

Non-alcoholic fatty liver disease (NAFLD) is the well-known disease of the liver in adults and children throughout the world. The main manifestations related to NAFLD are an unusual storage of lipid in hepatocytes (hepatic steatosis) and progression of inflammation for non-alcoholic steatohepatitis...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2020-04, Vol.39 (4), p.613-627
Main Authors: Ebrahimzadeh Leylabadlo, Hamed, Ghotaslou, Reza, Samadi Kafil, Hossein, Feizabadi, Mohammad Mehdi, Moaddab, Seyed Yaghoub, Farajnia, Safar, Sheykhsaran, Elham, Sanaie, Sarvin, Shanehbandi, Dariush, Bannazadeh Baghi, Hossein
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Environmental factors
Fatty liver
Fecal microflora
Hepatocytes
Inflammation
Internal Medicine
Intestinal microflora
Lipids
Literature reviews
Liver
Liver diseases
Medical Microbiology
Microbiota
Microorganisms
Probiotics
Review
Search engines
Steatosis
Transplantation
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Summary:Non-alcoholic fatty liver disease (NAFLD) is the well-known disease of the liver in adults and children throughout the world. The main manifestations related to NAFLD are an unusual storage of lipid in hepatocytes (hepatic steatosis) and progression of inflammation for non-alcoholic steatohepatitis (NASH). NAFLD is described as a multifactorial complication due to the genetic predisposition, metabolic functions, inflammatory, gut microbiota (GM), and environmental factors. The GM dysregulation among these factors is correlated to NAFLD development. In recent decades, advanced microbial profiling methods are continuing to shed light on the nature of the changes in the GM caused by NASH and NAFLD. In the current review, we aim to perform a literature review in different library databases and electronic searches (Science Direct, PubMed, and Google Scholar) which were randomly obtained. This will be done in order to provide an overview of the relation between GM and NAFLD, and the role of prebiotics, probiotics, and fecal microbiota transplantation (FMT), as potential therapeutic challenges for NAFLD.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-019-03746-1