Immunohistochemical analysis of the expression of cancer-associated fibroblast markers in esophageal cancer with and without neoadjuvant therapy

Esophageal carcinoma (EC) is one of the most aggressive human malignancies with high rates of resistance to conventional anticancer treatment. Cancer-associated fibroblasts (CAFs) are an important part of the tumor microenvironment and associated with tumor progression. COL11A1, SPARC, and CD90 have...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2020-05, Vol.476 (5), p.725-734
Main Authors: Galván, José A., Wiprächtiger, Julia, Slotta-Huspenina, Julia, Feith, Marcus, Ott, Katja, Kröll, Dino, Seiler, Christian A., Langer, Rupert
Format: Article
Language:English
Subjects:
Cancer therapies
CD90 antigen
Chemotherapy
Esophageal cancer
Esophageal carcinoma
Esophagus
Fibroblasts
Immunohistochemistry
Markers
Medicine
Medicine & Public Health
Original Article
Osteonectin
Pathology
Quality in Pathology
Regression analysis
Tumorigenesis
Tumors
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Summary:Esophageal carcinoma (EC) is one of the most aggressive human malignancies with high rates of resistance to conventional anticancer treatment. Cancer-associated fibroblasts (CAFs) are an important part of the tumor microenvironment and associated with tumor progression. COL11A1, SPARC, and CD90 have been identified as rather specific CAF markers, with COL11A1 expression particularly shown to influence response to chemotherapy. We investigated the impact of CAFs in esophageal cancer with a special focus on response to neoadjuvant treatment (nTX). Two collections of esophageal carcinomas were investigated: 164 cases treated with primary resection and 256 cases receiving nTX before resection. The expression of CAF markers was determined using next-generation tissue microarray (ngTMA®) technology and immunohistochemistry. The presence of COL11A1 and SPARC in fibroblasts within both primary resected cases and nTX-treated cases was associated with unfavorable clinicopathological variables such as higher (y)pT category and lymphatic invasion (p
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-019-02714-6