Evaluation of the relationships of the WBP1L gene with schizophrenia and the general psychopathology scale based on a case–control study

• Published in: American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2020-04, Vol.183 (3), p.164-171
• Main Authors: Guan, Fanglin, Ni, Tong, Han, Wei, Lin, Huali, Zhang, Bo, Chen, Gang, Zhu, Li, Liu, Dan, Zhang, Tianxiao
• Format: Article
• Language: English
• Subjects: Adult; Alleles; Brain - metabolism; Case-Control Studies; China; common polymorphisms; Computational Biology; eQTL; Female; Gene expression; Genetics; Genotype; Genotyping; Humans; Male; Membrane Proteins - genetics; Mental disorders; Middle Aged; miRNA; PANSS; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Psychopathology; Quantitative Trait Loci; Replication; Schizophrenia; Schizophrenia - genetics; Single-nucleotide polymorphism; WBP1L; WW Domains; Young Adult
• ISSN: 1552-4841; 1552-485X
• DOI: 10.1002/ajmg.b.32773

WBP1L is a target of microRNA 137 (miR‐137) and has been considered a candidate gene for schizophrenia (SCZ). To investigate the relationships between WBP1L and SCZ and its related symptom scales, a total of 5,993 Chinese Han subjects, including 2,128 SCZ patients and 3,865 controls, were enrolled. In addition, an independent sample set for replication study including 1,052 SCZ patients and 2,124 controls were also recruited. Thirty‐two tag single nucleotide polymorphisms (SNPs) located within gene region of WBP1L were selected for genotyping and analyzing. The expression quantitative trait loci (eQTL) effects for the targeted SNPs were investigated with gene expression data from multiple human tissues. Rs4147157 (OR = 0.84, p = 1.51 × 10−5) and rs284854 (OR = 1.14, p = 7.00 × 10−4) were significantly associated with SCZ disease status and these association signals were replicated in our replication sample. A significant association was identified between rs4147157 and the general (β = −.66, p = .001) and total (β = −.8, p = .0042) scores of positive and negative syndrome scale scores in SCZ patients. Both SNPs were significant eQTL for genes around WBP1L in human brain tissues including ARL3 and AS3MT. To conclude, SNPs rs4147157 and rs284854 were associated with SCZ in the Chinese Han population. Additionally, rs4147157 was significantly associated with specific symptom features of SCZ.