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The role of increased red cell distribution width as a negative prognostic marker in patients with COPD
Chronic obstructive pulmonary disease (COPD) remains a major burden with no clinically applicable biomarkers. To investigate the association of Red cell Distribution Width (RDW) values on admission with previous hospitalizations, need of non-invasive mechanical ventilation (NIMV) and long term oxyge...
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| Published in: | Pulmonary pharmacology & therapeutics 2020-02, Vol.60, p.101877-101877, Article 101877 |
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| container_end_page | 101877 |
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| container_start_page | 101877 |
| container_title | Pulmonary pharmacology & therapeutics |
| container_volume | 60 |
| creator | Karampitsakos, Theodoros Dimakou, Katerina Papaioannou, Ourania Chrysikos, Serafeim Kaponi, Maria Bouros, Demosthenes Tzouvelekis, Argyrios Hillas, Georgios |
| description | Chronic obstructive pulmonary disease (COPD) remains a major burden with no clinically applicable biomarkers.
To investigate the association of Red cell Distribution Width (RDW) values on admission with previous hospitalizations, need of non-invasive mechanical ventilation (NIMV) and long term oxygen therapy (LTOT) in patients with COPD.
Patients with AECOPD admitted to our department during 2018 were included in the study.
One hundred sixty patients were enrolled (M/F 95/65, median age 71.00 years, mean FEV1± SD = 46.6 ± 28.9). Median RDW was significantly higher for patients in need of NIMV (14.8, 95% CI: 14.2 to 15.6) than patients not in need of NIMV (13.5, 95% CI: 13.2 to 13.8) (p |
| doi_str_mv | 10.1016/j.pupt.2019.101877 |
| format | article |
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To investigate the association of Red cell Distribution Width (RDW) values on admission with previous hospitalizations, need of non-invasive mechanical ventilation (NIMV) and long term oxygen therapy (LTOT) in patients with COPD.
Patients with AECOPD admitted to our department during 2018 were included in the study.
One hundred sixty patients were enrolled (M/F 95/65, median age 71.00 years, mean FEV1± SD = 46.6 ± 28.9). Median RDW was significantly higher for patients in need of NIMV (14.8, 95% CI: 14.2 to 15.6) than patients not in need of NIMV (13.5, 95% CI: 13.2 to 13.8) (p < 0.001). Median RDW was significantly higher for patients in need of LTOT (14.2, 95% CI: 13.7 to 14.6) compared to patients not receiving LTOT (13.2, 95% CI: 12.5 to 13.6) (p = 0.001). Patients with hospitalization during the last 12 months had increased RDW values compared to patients with no hospitalizations [median RDW 14.3, (95% CI: 13.5 to 14.9) versus median RDW 13.5, (95% CI: 13.1 to 13.9)](p = 0.001).
Patients with COPD in need of LTOT, NIMV or patients with previous hospitalizations presented with increased RDW values. Increased RDW values could serve as a negative prognostic marker in patients with COPD.</description><identifier>ISSN: 1094-5539</identifier><identifier>EISSN: 1522-9629</identifier><identifier>DOI: 10.1016/j.pupt.2019.101877</identifier><identifier>PMID: 31843703</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; Biomarkers ; Chronic obstructive pulmonary disease ; Cohort Studies ; Erythrocyte Indices - physiology ; Erythrocytes - pathology ; Female ; Hospitalizations ; Humans ; Hypercapnia ; Long term oxygen therapy ; Male ; Non-invasive mechanical ventilation ; Noninvasive Ventilation ; Prognosis ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive - blood ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Red cell distribution width ; Severity of Illness Index</subject><ispartof>Pulmonary pharmacology & therapeutics, 2020-02, Vol.60, p.101877-101877, Article 101877</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-754651721fb0e39291b05be5fdc53a992b608c2ac71c797119d098487148d48e3</citedby><cites>FETCH-LOGICAL-c356t-754651721fb0e39291b05be5fdc53a992b608c2ac71c797119d098487148d48e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31843703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karampitsakos, Theodoros</creatorcontrib><creatorcontrib>Dimakou, Katerina</creatorcontrib><creatorcontrib>Papaioannou, Ourania</creatorcontrib><creatorcontrib>Chrysikos, Serafeim</creatorcontrib><creatorcontrib>Kaponi, Maria</creatorcontrib><creatorcontrib>Bouros, Demosthenes</creatorcontrib><creatorcontrib>Tzouvelekis, Argyrios</creatorcontrib><creatorcontrib>Hillas, Georgios</creatorcontrib><title>The role of increased red cell distribution width as a negative prognostic marker in patients with COPD</title><title>Pulmonary pharmacology & therapeutics</title><addtitle>Pulm Pharmacol Ther</addtitle><description>Chronic obstructive pulmonary disease (COPD) remains a major burden with no clinically applicable biomarkers.
To investigate the association of Red cell Distribution Width (RDW) values on admission with previous hospitalizations, need of non-invasive mechanical ventilation (NIMV) and long term oxygen therapy (LTOT) in patients with COPD.
Patients with AECOPD admitted to our department during 2018 were included in the study.
One hundred sixty patients were enrolled (M/F 95/65, median age 71.00 years, mean FEV1± SD = 46.6 ± 28.9). Median RDW was significantly higher for patients in need of NIMV (14.8, 95% CI: 14.2 to 15.6) than patients not in need of NIMV (13.5, 95% CI: 13.2 to 13.8) (p < 0.001). Median RDW was significantly higher for patients in need of LTOT (14.2, 95% CI: 13.7 to 14.6) compared to patients not receiving LTOT (13.2, 95% CI: 12.5 to 13.6) (p = 0.001). Patients with hospitalization during the last 12 months had increased RDW values compared to patients with no hospitalizations [median RDW 14.3, (95% CI: 13.5 to 14.9) versus median RDW 13.5, (95% CI: 13.1 to 13.9)](p = 0.001).
Patients with COPD in need of LTOT, NIMV or patients with previous hospitalizations presented with increased RDW values. Increased RDW values could serve as a negative prognostic marker in patients with COPD.</description><subject>Aged</subject><subject>Biomarkers</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cohort Studies</subject><subject>Erythrocyte Indices - physiology</subject><subject>Erythrocytes - pathology</subject><subject>Female</subject><subject>Hospitalizations</subject><subject>Humans</subject><subject>Hypercapnia</subject><subject>Long term oxygen therapy</subject><subject>Male</subject><subject>Non-invasive mechanical ventilation</subject><subject>Noninvasive Ventilation</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Pulmonary Disease, Chronic Obstructive - blood</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Red cell distribution width</subject><subject>Severity of Illness Index</subject><issn>1094-5539</issn><issn>1522-9629</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPxCAUhYnR-P4DLgxLNx15lFISN2Z8Jia60DWhcDsyzrQVqMZ_L82oSxfkEu45J5wPoRNKZpTQ6nw5G8YhzRihanqopdxC-1QwVqiKqe18J6oshOBqDx3EuCSEyJKLXbTHaV1ySfg-Wjy_Ag79CnDfYt_ZACaCwyEfC6sVdj6m4Jsx-b7Dn96lV2wiNriDhUn-A_AQ-kXXx-QtXpvwBiGn4CHvoEsxO7Jh_vh0dYR2WrOKcPwzD9HLzfXz_K54eLy9n18-FJaLKhVSlJWgktG2IcAVU7QhogHROiu4UYo1FaktM1ZSK5WkVDmi6rKWtKxdWQM_RGeb3Pyv9xFi0msfpyamg36MmnEmVa5fiSxlG6kNfYwBWj0Enzt8aUr0BFgv9QRYT4D1BnA2nf7kj80a3J_ll2gWXGwEkFt-eAg62szCgvMBbNKu9__lfwOUzYvZ</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Karampitsakos, Theodoros</creator><creator>Dimakou, Katerina</creator><creator>Papaioannou, Ourania</creator><creator>Chrysikos, Serafeim</creator><creator>Kaponi, Maria</creator><creator>Bouros, Demosthenes</creator><creator>Tzouvelekis, Argyrios</creator><creator>Hillas, Georgios</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202002</creationdate><title>The role of increased red cell distribution width as a negative prognostic marker in patients with COPD</title><author>Karampitsakos, Theodoros ; Dimakou, Katerina ; Papaioannou, Ourania ; Chrysikos, Serafeim ; Kaponi, Maria ; Bouros, Demosthenes ; Tzouvelekis, Argyrios ; Hillas, Georgios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-754651721fb0e39291b05be5fdc53a992b608c2ac71c797119d098487148d48e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Biomarkers</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cohort Studies</topic><topic>Erythrocyte Indices - physiology</topic><topic>Erythrocytes - pathology</topic><topic>Female</topic><topic>Hospitalizations</topic><topic>Humans</topic><topic>Hypercapnia</topic><topic>Long term oxygen therapy</topic><topic>Male</topic><topic>Non-invasive mechanical ventilation</topic><topic>Noninvasive Ventilation</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Pulmonary Disease, Chronic Obstructive - blood</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Red cell distribution width</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karampitsakos, Theodoros</creatorcontrib><creatorcontrib>Dimakou, Katerina</creatorcontrib><creatorcontrib>Papaioannou, Ourania</creatorcontrib><creatorcontrib>Chrysikos, Serafeim</creatorcontrib><creatorcontrib>Kaponi, Maria</creatorcontrib><creatorcontrib>Bouros, Demosthenes</creatorcontrib><creatorcontrib>Tzouvelekis, Argyrios</creatorcontrib><creatorcontrib>Hillas, Georgios</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pulmonary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karampitsakos, Theodoros</au><au>Dimakou, Katerina</au><au>Papaioannou, Ourania</au><au>Chrysikos, Serafeim</au><au>Kaponi, Maria</au><au>Bouros, Demosthenes</au><au>Tzouvelekis, Argyrios</au><au>Hillas, Georgios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of increased red cell distribution width as a negative prognostic marker in patients with COPD</atitle><jtitle>Pulmonary pharmacology & therapeutics</jtitle><addtitle>Pulm Pharmacol Ther</addtitle><date>2020-02</date><risdate>2020</risdate><volume>60</volume><spage>101877</spage><epage>101877</epage><pages>101877-101877</pages><artnum>101877</artnum><issn>1094-5539</issn><eissn>1522-9629</eissn><abstract>Chronic obstructive pulmonary disease (COPD) remains a major burden with no clinically applicable biomarkers.
To investigate the association of Red cell Distribution Width (RDW) values on admission with previous hospitalizations, need of non-invasive mechanical ventilation (NIMV) and long term oxygen therapy (LTOT) in patients with COPD.
Patients with AECOPD admitted to our department during 2018 were included in the study.
One hundred sixty patients were enrolled (M/F 95/65, median age 71.00 years, mean FEV1± SD = 46.6 ± 28.9). Median RDW was significantly higher for patients in need of NIMV (14.8, 95% CI: 14.2 to 15.6) than patients not in need of NIMV (13.5, 95% CI: 13.2 to 13.8) (p < 0.001). Median RDW was significantly higher for patients in need of LTOT (14.2, 95% CI: 13.7 to 14.6) compared to patients not receiving LTOT (13.2, 95% CI: 12.5 to 13.6) (p = 0.001). Patients with hospitalization during the last 12 months had increased RDW values compared to patients with no hospitalizations [median RDW 14.3, (95% CI: 13.5 to 14.9) versus median RDW 13.5, (95% CI: 13.1 to 13.9)](p = 0.001).
Patients with COPD in need of LTOT, NIMV or patients with previous hospitalizations presented with increased RDW values. Increased RDW values could serve as a negative prognostic marker in patients with COPD.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31843703</pmid><doi>10.1016/j.pupt.2019.101877</doi><tpages>1</tpages></addata></record> |
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| source | ScienceDirect Freedom Collection |
| subjects | Aged Biomarkers Chronic obstructive pulmonary disease Cohort Studies Erythrocyte Indices - physiology Erythrocytes - pathology Female Hospitalizations Humans Hypercapnia Long term oxygen therapy Male Non-invasive mechanical ventilation Noninvasive Ventilation Prognosis Prospective Studies Pulmonary Disease, Chronic Obstructive - blood Pulmonary Disease, Chronic Obstructive - physiopathology Red cell distribution width Severity of Illness Index |
| title | The role of increased red cell distribution width as a negative prognostic marker in patients with COPD |
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