Detection of hemodynamic impairment on 15O gas PET using visual assessment of arterial spin-labeling MR imaging in patients with moyamoya disease

• Published in: Journal of clinical neuroscience 2020-02, Vol.72, p.258-263
• Main Authors: Hara, Shoko, Tanaka, Yoji, Ueda, Yasuhiro, Abe, Daisu, Hayashi, Shihori, Inaji, Motoki, Maehara, Taketoshi, Ishii, Kenji, Nariai, Tadashi
• Format: Article
• Language: English
• Subjects: Arterial spin labeling; Cerebral perfusion; Moyamoya disease; Oxygen extraction fraction; Positron emission tomography
• ISSN: 0967-5868; 1532-2653
• DOI: 10.1016/j.jocn.2019.11.026

•The ASL score is a four-point visual assessment scale of ASL-MRI.•ASL score correlated with 15O-gas PET quantitative parameters in moyamoya disease.•ASL score (PLD = 2525 ms) showed the highest specificity (98.7%) for elevated OEF.•The ASL score might be used to assess hemodynamic impairment of moyamoya disease. It is unclear whether the visual assessment of noninvasive arterial spin labeling magnetic resonance imaging (ASL) can identify instances of hemodynamic compromise including an elevated oxygen extraction fraction (OEF) measured by 15O-gas positron emission tomography (PET). Here we evaluated the relationship between a four-point visual assessment system referred to as 'ASL scores' using ASL with two postlabeling delays (PLDs; 1525 ms and 2525 ms) and some quantitative hemodynamic parameters measured by PET. We retrospectively evaluated the cases of 18 Japanese patients with moyamoya disease who underwent ASL and PET. We compared the patients' regional ASL scores on two ASL images to the regional values of PET parameters, and we observed a significant trend in accord with the presumed clinical severity among all PET parameters and ASL scores (p