Association of variability in antibody binding affinity with a clinical course of anti-MAG neuropathy

Anti-myelin-associated glycoprotein (MAG) neuropathy is mediated by the binding of IgM M-proteins to the human natural killer-1 epitope of several glycoconjugates, including MAG and phosphacan. We recently reported that IgM M-proteins with a higher ratio of anti-phosphacan titer to anti-MAG titer (P...

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Bibliographic Details
Published in:Journal of neuroimmunology 2020-02, Vol.339, p.577127-577127, Article 577127
Main Authors: Matsui, Taro, Hamada, Yukihiro, Kuwahara, Motoi, Morise, Jyoji, Oka, Shogo, Kaida, Kenichi, Kusunoki, Susumu
Format: Article
Language:English
Subjects:
Anti-MAG neuropathy
MAG
P/M ratio
Phosphacan
Prognosis
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Summary:Anti-myelin-associated glycoprotein (MAG) neuropathy is mediated by the binding of IgM M-proteins to the human natural killer-1 epitope of several glycoconjugates, including MAG and phosphacan. We recently reported that IgM M-proteins with a higher ratio of anti-phosphacan titer to anti-MAG titer (P/M ratio) were associated with a progressive clinical course. Herein, we investigated the temporal variability of the P/M ratio. The results showed that P/M ratios in worsened cases were significantly increased relative to stable or improved cases. Thus, temporal variability in the specificity of IgM M-proteins may be related to the disease course of anti-MAG neuropathy. [Display omitted] •Δ P/M ratios are higher in a worsened patients than improve or stable patients.•ΔP/M ratios are correlated to ΔINCAT scores.•P/M ratios may be useful as a novel biomarker of anti-MAG neuropathy.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2019.577127