Comparison of salvage surgery for recurrent or residual head and neck squamous cell carcinoma

Abstract Objective Concomitant chemoradiation therapy is a standard treatment for head and neck cancer. Thus, salvage surgery has become a necessary treatment. The aim of the study was to evaluate the results of salvage surgery by each site of the head and neck, especially the oropharynx, hypopharyn...

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Published in:Japanese journal of clinical oncology 2020-03, Vol.50 (3), p.288-295
Main Authors: Maruo, Takashi, Zenda, Sadamoto, Shinozaki, Takeshi, Tomioka, Toshifumi, Okano, Wataru, Sakuraba, Minoru, Tahara, Makoto, Hayashi, Ryuichi
Format: Article
Language:English
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Summary:Abstract Objective Concomitant chemoradiation therapy is a standard treatment for head and neck cancer. Thus, salvage surgery has become a necessary treatment. The aim of the study was to evaluate the results of salvage surgery by each site of the head and neck, especially the oropharynx, hypopharynx and larynx. Methods This was a retrospective, single-institute study. The primary endpoint was overall survival. Secondary endpoints were disease-free survival, the locoregional control rate after salvage surgery, the indication rate for salvage surgery, the reasons for contraindications to salvage surgery, the post-operative complication rate and the predictors of survival. Results Three-year overall survival after salvage surgery was 58.8% in the salvage surgery group and 8.59% in the other treatment group (P 
ISSN:1465-3621
1465-3621
DOI:10.1093/jjco/hyz176