A Brief Review on the Non-protein Amino Acid, Gamma-amino Butyric Acid (GABA): Its Production and Role in Microbes

Gamma-Aminobutyric acid (GABA) is a non-protein amino acid widely distributed in nature. It is produced through irreversible α-decarboxylation of glutamate by enzyme glutamate decarboxylase (GAD). GABA and GAD have been found in plants, animals, and microorganisms. GABA is distributed throughout the...

Full description

Saved in:
Bibliographic Details
Published in:Current microbiology 2020-04, Vol.77 (4), p.534-544
Main Authors: Sarasa, Sabna B., Mahendran, Ramasamy, Muthusamy, Gayathri, Thankappan, Bency, Selta, Daniel Raja Femil, Angayarkanni, Jayaraman
Format: Article
Language:English
Subjects:
Amino acids
Biomedical and Life Sciences
Biotechnology
Blood pressure
Butyric acid
Decarboxylation
Food industry
Food processing industry
Heart rate
Life Sciences
Microbiology
Microorganisms
Proteins
Researchers
Review Article
γ-Aminobutyric acid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c441t-61e0adf838b8ae82866f21f3a6c7b3f22b0a7a3ab4b39b72bf3828dd7943aace3
cites cdi_FETCH-LOGICAL-c441t-61e0adf838b8ae82866f21f3a6c7b3f22b0a7a3ab4b39b72bf3828dd7943aace3
container_end_page 544
container_issue 4
container_start_page 534
container_title Current microbiology
container_volume 77
creator Sarasa, Sabna B.
Mahendran, Ramasamy
Muthusamy, Gayathri
Thankappan, Bency
Selta, Daniel Raja Femil
Angayarkanni, Jayaraman
description Gamma-Aminobutyric acid (GABA) is a non-protein amino acid widely distributed in nature. It is produced through irreversible α-decarboxylation of glutamate by enzyme glutamate decarboxylase (GAD). GABA and GAD have been found in plants, animals, and microorganisms. GABA is distributed throughout the human body and it is involved in the regulation of cardiovascular conditions such as blood pressure and heart rate, and plays a role in the reduction of anxiety and pain. Although researchers had produced GABA by chemical method earlier it became less acceptable as it pollutes the environment. Researchers now use a more promising microbial method for the production of GABA. In the drug and food industry, demand for GABA is immense. So, large scale conversion of GABA by microbes has got much attention. So this review focuses on the isolation source, production, and functions of GABA in the microbial system. We also summarize the mechanism of action of GABA and its shunt pathway.
doi_str_mv 10.1007/s00284-019-01839-w
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2327938854</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2377614090</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-61e0adf838b8ae82866f21f3a6c7b3f22b0a7a3ab4b39b72bf3828dd7943aace3</originalsourceid><addsrcrecordid>eNp9kVFrFDEQx4NY7Nn6BXyQgC8VjE0y6W7i217Ra6FaKfockt1ZTbndtMmuR7-96V214EMfQiDzm_9k-BHyWvAPgvP6OHMutWJcmHI0GLZ5RhZCgWTcGPGcLDgoYLo6EfvkZc7XnAtpuHhB9kFopQxUC5IaukwBe3qFvwNuaBzp9Avp1ziymxQnDCNthjBG2rShe09Xbhgcc9uX5TzdpdBuK_Ro1Sybdx_p-ZTptxS7uZ1CyXJjR6_iGmnJ-RLaFD3mQ7LXu3XGVw_3Afnx-dP30zN2cbk6P20uWKuUmFglkLuu16C9dqilrqpeih5c1dYeeik9d7UD55UH42vpeyhQ19VGgXMtwgE52uWWRW5nzJMdQm5xvXYjxjlbCbI2oPWJKujb_9DrOKex_K5QdV0JxQ0vlNxRZY-cE_b2JoXBpTsruL03YndGbDFit0bspjS9eYie_YDdv5a_CgoAOyCX0vgT0-PsJ2L_AL1BlNc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2377614090</pqid></control><display><type>article</type><title>A Brief Review on the Non-protein Amino Acid, Gamma-amino Butyric Acid (GABA): Its Production and Role in Microbes</title><source>Springer Nature</source><creator>Sarasa, Sabna B. ; Mahendran, Ramasamy ; Muthusamy, Gayathri ; Thankappan, Bency ; Selta, Daniel Raja Femil ; Angayarkanni, Jayaraman</creator><creatorcontrib>Sarasa, Sabna B. ; Mahendran, Ramasamy ; Muthusamy, Gayathri ; Thankappan, Bency ; Selta, Daniel Raja Femil ; Angayarkanni, Jayaraman</creatorcontrib><description>Gamma-Aminobutyric acid (GABA) is a non-protein amino acid widely distributed in nature. It is produced through irreversible α-decarboxylation of glutamate by enzyme glutamate decarboxylase (GAD). GABA and GAD have been found in plants, animals, and microorganisms. GABA is distributed throughout the human body and it is involved in the regulation of cardiovascular conditions such as blood pressure and heart rate, and plays a role in the reduction of anxiety and pain. Although researchers had produced GABA by chemical method earlier it became less acceptable as it pollutes the environment. Researchers now use a more promising microbial method for the production of GABA. In the drug and food industry, demand for GABA is immense. So, large scale conversion of GABA by microbes has got much attention. So this review focuses on the isolation source, production, and functions of GABA in the microbial system. We also summarize the mechanism of action of GABA and its shunt pathway.</description><identifier>ISSN: 0343-8651</identifier><identifier>EISSN: 1432-0991</identifier><identifier>DOI: 10.1007/s00284-019-01839-w</identifier><identifier>PMID: 31844936</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Amino acids ; Biomedical and Life Sciences ; Biotechnology ; Blood pressure ; Butyric acid ; Decarboxylation ; Food industry ; Food processing industry ; Heart rate ; Life Sciences ; Microbiology ; Microorganisms ; Proteins ; Researchers ; Review Article ; γ-Aminobutyric acid</subject><ispartof>Current microbiology, 2020-04, Vol.77 (4), p.534-544</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Current Microbiology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-61e0adf838b8ae82866f21f3a6c7b3f22b0a7a3ab4b39b72bf3828dd7943aace3</citedby><cites>FETCH-LOGICAL-c441t-61e0adf838b8ae82866f21f3a6c7b3f22b0a7a3ab4b39b72bf3828dd7943aace3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31844936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sarasa, Sabna B.</creatorcontrib><creatorcontrib>Mahendran, Ramasamy</creatorcontrib><creatorcontrib>Muthusamy, Gayathri</creatorcontrib><creatorcontrib>Thankappan, Bency</creatorcontrib><creatorcontrib>Selta, Daniel Raja Femil</creatorcontrib><creatorcontrib>Angayarkanni, Jayaraman</creatorcontrib><title>A Brief Review on the Non-protein Amino Acid, Gamma-amino Butyric Acid (GABA): Its Production and Role in Microbes</title><title>Current microbiology</title><addtitle>Curr Microbiol</addtitle><addtitle>Curr Microbiol</addtitle><description>Gamma-Aminobutyric acid (GABA) is a non-protein amino acid widely distributed in nature. It is produced through irreversible α-decarboxylation of glutamate by enzyme glutamate decarboxylase (GAD). GABA and GAD have been found in plants, animals, and microorganisms. GABA is distributed throughout the human body and it is involved in the regulation of cardiovascular conditions such as blood pressure and heart rate, and plays a role in the reduction of anxiety and pain. Although researchers had produced GABA by chemical method earlier it became less acceptable as it pollutes the environment. Researchers now use a more promising microbial method for the production of GABA. In the drug and food industry, demand for GABA is immense. So, large scale conversion of GABA by microbes has got much attention. So this review focuses on the isolation source, production, and functions of GABA in the microbial system. We also summarize the mechanism of action of GABA and its shunt pathway.</description><subject>Amino acids</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Blood pressure</subject><subject>Butyric acid</subject><subject>Decarboxylation</subject><subject>Food industry</subject><subject>Food processing industry</subject><subject>Heart rate</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Microorganisms</subject><subject>Proteins</subject><subject>Researchers</subject><subject>Review Article</subject><subject>γ-Aminobutyric acid</subject><issn>0343-8651</issn><issn>1432-0991</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kVFrFDEQx4NY7Nn6BXyQgC8VjE0y6W7i217Ra6FaKfockt1ZTbndtMmuR7-96V214EMfQiDzm_9k-BHyWvAPgvP6OHMutWJcmHI0GLZ5RhZCgWTcGPGcLDgoYLo6EfvkZc7XnAtpuHhB9kFopQxUC5IaukwBe3qFvwNuaBzp9Avp1ziymxQnDCNthjBG2rShe09Xbhgcc9uX5TzdpdBuK_Ro1Sybdx_p-ZTptxS7uZ1CyXJjR6_iGmnJ-RLaFD3mQ7LXu3XGVw_3Afnx-dP30zN2cbk6P20uWKuUmFglkLuu16C9dqilrqpeih5c1dYeeik9d7UD55UH42vpeyhQ19VGgXMtwgE52uWWRW5nzJMdQm5xvXYjxjlbCbI2oPWJKujb_9DrOKex_K5QdV0JxQ0vlNxRZY-cE_b2JoXBpTsruL03YndGbDFit0bspjS9eYie_YDdv5a_CgoAOyCX0vgT0-PsJ2L_AL1BlNc</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Sarasa, Sabna B.</creator><creator>Mahendran, Ramasamy</creator><creator>Muthusamy, Gayathri</creator><creator>Thankappan, Bency</creator><creator>Selta, Daniel Raja Femil</creator><creator>Angayarkanni, Jayaraman</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20200401</creationdate><title>A Brief Review on the Non-protein Amino Acid, Gamma-amino Butyric Acid (GABA): Its Production and Role in Microbes</title><author>Sarasa, Sabna B. ; Mahendran, Ramasamy ; Muthusamy, Gayathri ; Thankappan, Bency ; Selta, Daniel Raja Femil ; Angayarkanni, Jayaraman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-61e0adf838b8ae82866f21f3a6c7b3f22b0a7a3ab4b39b72bf3828dd7943aace3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amino acids</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Blood pressure</topic><topic>Butyric acid</topic><topic>Decarboxylation</topic><topic>Food industry</topic><topic>Food processing industry</topic><topic>Heart rate</topic><topic>Life Sciences</topic><topic>Microbiology</topic><topic>Microorganisms</topic><topic>Proteins</topic><topic>Researchers</topic><topic>Review Article</topic><topic>γ-Aminobutyric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sarasa, Sabna B.</creatorcontrib><creatorcontrib>Mahendran, Ramasamy</creatorcontrib><creatorcontrib>Muthusamy, Gayathri</creatorcontrib><creatorcontrib>Thankappan, Bency</creatorcontrib><creatorcontrib>Selta, Daniel Raja Femil</creatorcontrib><creatorcontrib>Angayarkanni, Jayaraman</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sarasa, Sabna B.</au><au>Mahendran, Ramasamy</au><au>Muthusamy, Gayathri</au><au>Thankappan, Bency</au><au>Selta, Daniel Raja Femil</au><au>Angayarkanni, Jayaraman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Brief Review on the Non-protein Amino Acid, Gamma-amino Butyric Acid (GABA): Its Production and Role in Microbes</atitle><jtitle>Current microbiology</jtitle><stitle>Curr Microbiol</stitle><addtitle>Curr Microbiol</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>77</volume><issue>4</issue><spage>534</spage><epage>544</epage><pages>534-544</pages><issn>0343-8651</issn><eissn>1432-0991</eissn><abstract>Gamma-Aminobutyric acid (GABA) is a non-protein amino acid widely distributed in nature. It is produced through irreversible α-decarboxylation of glutamate by enzyme glutamate decarboxylase (GAD). GABA and GAD have been found in plants, animals, and microorganisms. GABA is distributed throughout the human body and it is involved in the regulation of cardiovascular conditions such as blood pressure and heart rate, and plays a role in the reduction of anxiety and pain. Although researchers had produced GABA by chemical method earlier it became less acceptable as it pollutes the environment. Researchers now use a more promising microbial method for the production of GABA. In the drug and food industry, demand for GABA is immense. So, large scale conversion of GABA by microbes has got much attention. So this review focuses on the isolation source, production, and functions of GABA in the microbial system. We also summarize the mechanism of action of GABA and its shunt pathway.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31844936</pmid><doi>10.1007/s00284-019-01839-w</doi><tpages>11</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0343-8651
ispartof Current microbiology, 2020-04, Vol.77 (4), p.534-544
issn 0343-8651
1432-0991
language eng
recordid cdi_proquest_miscellaneous_2327938854
source Springer Nature
subjects Amino acids
Biomedical and Life Sciences
Biotechnology
Blood pressure
Butyric acid
Decarboxylation
Food industry
Food processing industry
Heart rate
Life Sciences
Microbiology
Microorganisms
Proteins
Researchers
Review Article
γ-Aminobutyric acid
title A Brief Review on the Non-protein Amino Acid, Gamma-amino Butyric Acid (GABA): Its Production and Role in Microbes
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T01%3A02%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Brief%20Review%20on%20the%20Non-protein%20Amino%20Acid,%20Gamma-amino%20Butyric%20Acid%20(GABA):%20Its%20Production%20and%20Role%20in%20Microbes&rft.jtitle=Current%20microbiology&rft.au=Sarasa,%20Sabna%20B.&rft.date=2020-04-01&rft.volume=77&rft.issue=4&rft.spage=534&rft.epage=544&rft.pages=534-544&rft.issn=0343-8651&rft.eissn=1432-0991&rft_id=info:doi/10.1007/s00284-019-01839-w&rft_dat=%3Cproquest_cross%3E2377614090%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c441t-61e0adf838b8ae82866f21f3a6c7b3f22b0a7a3ab4b39b72bf3828dd7943aace3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2377614090&rft_id=info:pmid/31844936&rfr_iscdi=true