p-TsOH-mediated synthesis of substituted 2,4-diaryl-3-sulfonylquinolines from functionalized 2-aminobenzophenones and aromatic β-ketosulfones under microwave irradiation

This study describes an efficient protocol for the preparation of substituted 2,4-diaryl-3-sulfonylquinolines from functionalized 2-aminobenzophenones and aromatic β-ketosulfones by using p-toluenesulfonic acid monohydrate under microwave irradiation. In this atom-economical synthetic route, a serie...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2020-01, Vol.18 (2), p.305-315
Main Authors: Chan, Chieh-Kai, Lai, Chien-Yu, Lo, Wei-Chih, Cheng, Yu-Ting, Chang, Meng-Yang, Wang, Cheng-Chung
Format: Article
Language:English
Subjects:
Crystal structure
Crystallography
Crystals
Functional groups
Irradiation
Single crystals
Substitutes
X ray analysis
X-ray diffraction
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Summary:This study describes an efficient protocol for the preparation of substituted 2,4-diaryl-3-sulfonylquinolines from functionalized 2-aminobenzophenones and aromatic β-ketosulfones by using p-toluenesulfonic acid monohydrate under microwave irradiation. In this atom-economical synthetic route, a series of pharmaceutically active 3-arylsulfonylquinolines with good functional group tolerance are prepared in good to excellent yields. Some structures are confirmed by single-crystal X-ray diffraction analysis.
ISSN:1477-0520
1477-0539
DOI:10.1039/c9ob02445j