Human leukocyte antigen class I (A, B, C) and class II (DPB1, DQB1, DRB1) allele and haplotype variation in Black South African individuals

South Africa has a population of 58.78 million, of which 80.7% are Black African individuals, representing 9 predominant ethnic/linguistic groups (Zulu, Xhosa, Pedi, Tswana, South Sotho, Tsonga, Swati, Venda and Ndebele). HIV-1 and Mycobacterium tuberculosis infection are the leading causes of death...

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Bibliographic Details
Published in:Human immunology 2020-01, Vol.81 (1), p.6-7
Main Authors: Loubser, Shayne, Paximadis, Maria, Gentle, Nikki L., Puren, Adrian, Tiemessen, Caroline T.
Format: Article
Language:English
Subjects:
Black African
HLA class I alleles
HLA class II alleles
HLA haplotypes
South African population
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Summary:South Africa has a population of 58.78 million, of which 80.7% are Black African individuals, representing 9 predominant ethnic/linguistic groups (Zulu, Xhosa, Pedi, Tswana, South Sotho, Tsonga, Swati, Venda and Ndebele). HIV-1 and Mycobacterium tuberculosis infection are the leading causes of death (7.8% and 5.9%, respectively) in this population group. To provide reference HLA allele and haplotype data for studies of gene-associations with infectious/non-infectious diseases or vaccine development, we have updated previously published HLA class I (A, B, C) and class II DRB1 genotypes and determined high-resolution class II (DPB1, DQB1) genotypes for n = 142 healthy, unrelated Black South African individuals.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2019.12.003