Antimicrobial secondary metabolites from the stem barks and leaves of Monotes kerstingii Gilg (Dipterocarpaceae)

In the search for bioactive natural products from the African flora, three previously undescribed compounds including one stilbene-coumarin derivative (1), one coumarin-carbinol (2) and one fatty glycoside (3) were isolated from the stem bark and leaves of Monotes kerstingii, together with sixteen k...

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Bibliographic Details
Published in:Fitoterapia 2019-09, Vol.137 (NA), p.104239, Article 104239
Main Authors: Fotso, Ghislain Wabo, Mogue Kamdem, Linda, Dube, Mthandazo, Fobofou, Serge Alain, Ndjie Ebene, Albert, Arnold, Norbert, Tchaleu Ngadjui, Bonaventure
Format: Article
Language:English
Subjects:
Active control
Anthelmintic activity, antimicrobial activity
Anthelmintic agents
Antibacterial activity
Antifungal activity
Antimicrobial activity
Antimicrobial agents
Antiparasitic agents
Bark
Coumarin
Coumarin-carbinol
Erythromycin
Fatty glycoside
Flora
Fungicides
Inhibition
Leaves
Metabolites
Natural products
NMR
Nuclear magnetic resonance
Secondary metabolites
Stilbene
Stilbene-coumarin
Terbinafine
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Summary:In the search for bioactive natural products from the African flora, three previously undescribed compounds including one stilbene-coumarin derivative (1), one coumarin-carbinol (2) and one fatty glycoside (3) were isolated from the stem bark and leaves of Monotes kerstingii, together with sixteen known compounds (4–19). The structures of the isolated compounds were elucidated based on their NMR and MS spectroscopic data and by comparison of these data with those previously reported in the literature. Compounds 1–19 were screened for anthelmintic and antimicrobial activity. None of the compounds exhibited significant anthelmintic activity. However, compounds 4, 5, 8 and 14 displayed interesting antibacterial activity against B. subtilis at a concentration of 100 μM with respective inhibition percentages of 99, 79, 71 and 100%, respectively, compared to erythromycin used as positive control. In addition, at the same concentration, compound 6 showed remarkable antifungal activity against Septoria tritici with 93.6% growth inhibition and was found to be more active than the positive controls epoconazole and terbinafine displaying 76.6 and 84.3%, respectively . [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2019.104239