The (ir)relevance of the abandoned criterion II for the diagnosis of serrated polyposis syndrome: a retrospective cohort study

The World Health Organization (WHO) recently updated the diagnostic criteria for serrated polyposis syndrome (SPS). One of the three previous diagnostic criteria (criterion II 2010 ) is now abandoned : ≥ 1 serrated polyp (SP) proximal to the sigmoid in a first-degree relative (FDR) of a patient with...

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Bibliographic Details
Published in:Familial cancer 2020-04, Vol.19 (2), p.153-160
Main Authors: Bleijenberg, Arne G.C., IJspeert, Joep E.G., Rodríguez-Alcalde, Daniel, Carballal, Sabela, Visser, Maurits R., Pellise, Maria, Koornstra, Jan Jacob, Rana, Salman A., Latchford, Andrew, Balaguer, Francesc, Dekker, Evelien
Format: Article
Language:English
Subjects:
Adenomatous Polyposis Coli - diagnosis
Adenomatous Polyposis Coli - epidemiology
Adenomatous Polyposis Coli - genetics
Adenomatous Polyposis Coli - pathology
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cohort analysis
Colon
Colonoscopy
Colonoscopy - statistics & numerical data
Diagnosis
Epidemiology
Family
Female
Human Genetics
Humans
Incidence
Kaplan-Meier Estimate
Male
Middle Aged
Original Article
Parents
Polyposis
Population Surveillance
Regression Analysis
Retrospective Studies
Siblings
Surveillance
Syndrome
World Health Organization
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Summary:The World Health Organization (WHO) recently updated the diagnostic criteria for serrated polyposis syndrome (SPS). One of the three previous diagnostic criteria (criterion II 2010 ) is now abandoned : ≥ 1 serrated polyp (SP) proximal to the sigmoid in a first-degree relative (FDR) of a patient with SPS. Individuals fulfilling this abandoned criterion now receive the same surveillance recommendations as all FDRs of patients with SPS. We aimed to compare the incidence of advanced neoplasia (AN) in FDRs with vs. without fulfillment of the abandoned criterion II 2010 . We retrospectively recruited FDRs of patients with SPS who underwent a colonoscopy, and stratified them according to fulfilment of criterion II 2010 at baseline. Our primary and secondary outcomes were AN incidence during surveillance and at baseline, respectively. We included 224 FDRs of patients with SPS, of whom 36 (16%) fulfilled criterion II 2010 at baseline. One hundred and five underwent surveillance after baseline. Criterion II 2010 -positive FDRs were at increased risk of AN, both during surveillance (hazard ratio 8.94, 95% CI 2.15–37.1, p = .003) as well as at baseline (adjusted odds-ratio 9.30, 95% CI 3.7–23.3, p 
ISSN:1389-9600
1573-7292
DOI:10.1007/s10689-019-00156-2