Biomechanical issues of tissue-engineered constructs for articular cartilage regeneration: in vitro and in vivo approaches

Given the limited regenerative capacity of injured articular cartilage, the absence of suitable therapeutic options has encouraged tissue-engineering approaches for its regeneration or replacement. Published articles in any language identified in PubMed and Scopus electronic databases up to August 2...

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Bibliographic Details
Published in:British medical bulletin 2019-12, Vol.132 (1), p.53-80
Main Authors: Cipollaro, Lucio, Ciardulli, Maria Camilla, Della Porta, Giovanna, Peretti, Giuseppe M, Maffulli, Nicola
Format: Article
Language:English
Subjects:
Biomechanical Phenomena - physiology
Bioprinting - methods
Cartilage, Articular - injuries
Cartilage, Articular - physiology
Humans
Regeneration - physiology
Tissue Engineering - methods
Tissue Scaffolds
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Summary:Given the limited regenerative capacity of injured articular cartilage, the absence of suitable therapeutic options has encouraged tissue-engineering approaches for its regeneration or replacement. Published articles in any language identified in PubMed and Scopus electronic databases up to August 2019 about the in vitro and in vivo properties of cartilage engineered constructs. A total of 64 articles were included following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Regenerated cartilage lacks the biomechanical and biological properties of native articular cartilage. There are many different approaches about the development of the architecture and the composition of the scaffolds. Novel tissue engineering strategies focus on the development of cartilaginous biomimetic materials able to repair cartilage lesions in association to cell, trophic factors and gene therapies. A multi-layer design and a zonal organization of the constructs may lead to achieve cartilage regeneration.
ISSN:0007-1420
1471-8391
DOI:10.1093/bmb/ldz034