The hallmarks of GSK-3 in morphogenesis and embryonic development metabolism in arthropods

• Published in: Insect biochemistry and molecular biology 2020-03, Vol.118, p.103307-103307, Article 103307
• Main Authors: Waltero, Camila, Martins, Renato, Calixto, Christiano, da Fonseca, Rodrigo Nunes, Abreu, Leonardo Araujo de, da Silva Vaz, Itabajara, Logullo, Carlos
• Format: Article
• Language: English
• Subjects: Arthropod; Arthropod vectors; Embryonic development; Glycogen synthase kinase-3; Metabolism control; Morphogenesis
• ISSN: 0965-1748; 1879-0240
• DOI: 10.1016/j.ibmb.2019.103307

Several research groups around the world have studied diverse aspects of energy metabolism in arthropod disease vectors, with the aim of discovering potential control targets. As in all oviparous organisms, arthropod embryonic development is characterized by the mobilization of maternally-derived metabolites for the formation of new tissues and organs. Glycogen synthase kinase-3 (GSK-3) is a serine-threonine kinase described as an important regulator of metabolism and development in a wide range of organisms. GSK-3 was first identified based on its action upon glycogen synthase, a central enzyme in glycogen biosynthesis. Currently, it is recognized as a key component of multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, cell migration, and immune response. The present review will describe the current knowledge on GSK-3 activation and its role in morphogenesis and embryonic metabolism in arthropods. Altogether, the information discussed here can spark new approaches and strategies for further studies, enhancing our understanding of these important arthropod vectors and strengthening the resources in the search for novel control methods. [Display omitted] •GSK-3 is a central regulatory enzyme in arthropod metabolism and embryogenesis.•GSK-3 and Wnt signaling are required for embryo polarity and segmentation processes.•GSK-3 is a putative candidate for the control of arthropod vectors.•GSK-3 has roles in vector-parasite interaction and infectious diseases.