THC exposure during adolescence does not modify nicotine reinforcing effects and relapse in adult male mice

Rationale Cannabis use is typically initiated during adolescence, and different studies suggest that adolescent cannabinoid exposure may increase the risk for drug addiction in adulthood. Objectives This study investigated the effects of adolescent exposure to the main psychoactive component of cann...

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Bibliographic Details
Published in:Psychopharmacology 2020-03, Vol.237 (3), p.801-809
Main Authors: Flores, África, Maldonado, Rafael, Berrendero, Fernando
Format: Article
Language:English
Subjects:
Adolescence
Adolescents
Adults
Biomedical and Life Sciences
Biomedicine
Cannabinoids
Cannabis
Child development
Drug addiction
Drug self-administration
Extinction behavior
Marijuana
Neurosciences
Nicotine
Original Investigation
Pharmacology/Toxicology
Psychiatry
Reinstatement
Teenagers
Tetrahydrocannabinol
THC
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Summary:Rationale Cannabis use is typically initiated during adolescence, and different studies suggest that adolescent cannabinoid exposure may increase the risk for drug addiction in adulthood. Objectives This study investigated the effects of adolescent exposure to the main psychoactive component of cannabis, ∆ 9 -tetrahydrocannabinol (THC), in the reinforcing properties of nicotine in adult male mice. Possible alterations in relapse to nicotine-seeking behaviour in adult animals due to THC adolescent exposure were also evaluated. Methods Adolescent mice were exposed to escalating doses of THC from PND35 to PND49. When mice reached adulthood (PND70), surgical procedures were applied for further behavioural evaluation. Nicotine self-administration sessions were conducted consecutively for 10 days. Following extinction, mice were tested for cue- and stress-induced reinstatement of nicotine-seeking behaviour. Results Adolescent THC treatment did not modify acquisition and extinction of nicotine self-administration in adulthood. Moreover, THC exposure did not alter relapse to nicotine seeking induced by stress or nicotine-associated cues. Conclusions These results suggest that a history of exposure to THC during adolescence under these particular conditions does not modify the reinforcing effects and seeking behaviour of nicotine in the adult period.
ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-019-05416-8