Immune-neuroendocrine and metabolic disorders in human and experimental T. cruzi infection: New clues for understanding Chagas disease pathology

Studies in mice undergoing acute Trypanosoma cruzi infection and patients with Chagas disease, led to identify several immune-neuroendocrine disturbances and metabolic disorders. Here, we review relevant findings concerning such abnormalities and discuss their possible influence on disease physiopat...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Molecular basis of disease 2020-03, Vol.1866 (3), p.165642-165642, Article 165642
Main Authors: González, Florencia B., Villar, Silvina R., Pacini, M. Florencia, Bottasso, Oscar A., Pérez, Ana R.
Format: Article
Language:English
Subjects:
Adipose tissue
Chagas disease
Glucocorticoids
Hypothalamus-pituitary-adrenal axis
IL-1 beta
PPAR-γ
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Summary:Studies in mice undergoing acute Trypanosoma cruzi infection and patients with Chagas disease, led to identify several immune-neuroendocrine disturbances and metabolic disorders. Here, we review relevant findings concerning such abnormalities and discuss their possible influence on disease physiopathology. •T. cruzi infection activates neuro-endocrine pathways.•T. cruzi infection is associated to metabolic changes.•T. cruzi infects endocrine glands.•Sympathetic nervous system regulates early T. cruzi infection.
ISSN:0925-4439
1879-260X
DOI:10.1016/j.bbadis.2019.165642