Loading…

Cardiovascular Risk Assessment for Noncardiac Surgery: Are We Ready for Biomarkers?

Biomarkers aided perioperative cardiac assessment is a relatively new concept. Cardiac biomarkers with historical significance (aspartate transaminase, dehydrogenase, creatinine kinase and myoglobin) have paved the way for traditional biomarkers (cardiac troponin, C-reactive protein, lipoprotein). C...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiothoracic and vascular anesthesia 2020-07, Vol.34 (7), p.1914-1924
Main Authors: Dhir, Shalini, Dhir, Achal
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c356t-7d58292ce3f8b2d72a8794e7fd789a21cdf4be043b4bdc55369c1f0224237faf3
cites cdi_FETCH-LOGICAL-c356t-7d58292ce3f8b2d72a8794e7fd789a21cdf4be043b4bdc55369c1f0224237faf3
container_end_page 1924
container_issue 7
container_start_page 1914
container_title Journal of cardiothoracic and vascular anesthesia
container_volume 34
creator Dhir, Shalini
Dhir, Achal
description Biomarkers aided perioperative cardiac assessment is a relatively new concept. Cardiac biomarkers with historical significance (aspartate transaminase, dehydrogenase, creatinine kinase and myoglobin) have paved the way for traditional biomarkers (cardiac troponin, C-reactive protein, lipoprotein). Contemporary biomarkers like natriuretic peptides (BNP and ProBNP) are validated risk markers in both acute and chronic cardiac diseases and are showing remarkable promise in predicting serious cardiovascular complications after non-cardiac surgery. This review is intended to provide a critical overview of traditional and contemporary biomarkers for perioperative cardiovascular assessment and management. This review also discusses the potential utility of newer biomarkers like galectin-3, sST-2, GDF-15, TNF-alpha, MiRNAs and many others that can predict inflammation, cardiac remodeling, injury and endogenous stress and need further investigations to establish their clinical utility. Though promising, biomarker led perioperative care is still in infancy and it has not been determined that it can improve clinical outcomes.
doi_str_mv 10.1053/j.jvca.2019.10.014
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2330060457</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S105307701931047X</els_id><sourcerecordid>2330060457</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-7d58292ce3f8b2d72a8794e7fd789a21cdf4be043b4bdc55369c1f0224237faf3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotlb_gAfZo5et-dhsdkWQWvyCotAqHkM2mUj6tTXpFvrvzdrq0dMMwzMvMw9C5wT3CebsatqfbrTqU0zKOOhjkh2gLuGMpkVG6WHsI5ViIXAHnYQwxZgQzsUx6jBS5DmlpIsmQ-WNqzcq6GaufDJ2YZYMQoAQFrBcJ7b2yUu91C2ldDJp_Cf47XUy8JB8QDIGZbY_0J2rF8rPwIfbU3Rk1TzA2b720PvD_dvwKR29Pj4PB6NUM56vU2F4QUuqgdmiokZQVYgyA2GNKEpFiTY2qwBnrMoqozlneamJxZRmlAmrLOuhy13uytdfDYS1XLigYT5XS6ibICljGOc44yKidIdqX4fgwcqVd_HerSRYtprkVLYyZSuznUWZcelin99UCzB_K7_2InCzAyB-uXHgZdAOlhqM86DX0tTuv_xvoOaFNA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2330060457</pqid></control><display><type>article</type><title>Cardiovascular Risk Assessment for Noncardiac Surgery: Are We Ready for Biomarkers?</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Dhir, Shalini ; Dhir, Achal</creator><creatorcontrib>Dhir, Shalini ; Dhir, Achal</creatorcontrib><description>Biomarkers aided perioperative cardiac assessment is a relatively new concept. Cardiac biomarkers with historical significance (aspartate transaminase, dehydrogenase, creatinine kinase and myoglobin) have paved the way for traditional biomarkers (cardiac troponin, C-reactive protein, lipoprotein). Contemporary biomarkers like natriuretic peptides (BNP and ProBNP) are validated risk markers in both acute and chronic cardiac diseases and are showing remarkable promise in predicting serious cardiovascular complications after non-cardiac surgery. This review is intended to provide a critical overview of traditional and contemporary biomarkers for perioperative cardiovascular assessment and management. This review also discusses the potential utility of newer biomarkers like galectin-3, sST-2, GDF-15, TNF-alpha, MiRNAs and many others that can predict inflammation, cardiac remodeling, injury and endogenous stress and need further investigations to establish their clinical utility. Though promising, biomarker led perioperative care is still in infancy and it has not been determined that it can improve clinical outcomes.</description><identifier>ISSN: 1053-0770</identifier><identifier>EISSN: 1532-8422</identifier><identifier>DOI: 10.1053/j.jvca.2019.10.014</identifier><identifier>PMID: 31866221</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Biomarkers ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; cardiovascular system ; Heart Disease Risk Factors ; heart failure ; Humans ; Natriuretic Peptide, Brain ; Peptide Fragments ; perioperative care ; Prognosis ; Risk Assessment ; Risk Factors</subject><ispartof>Journal of cardiothoracic and vascular anesthesia, 2020-07, Vol.34 (7), p.1914-1924</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-7d58292ce3f8b2d72a8794e7fd789a21cdf4be043b4bdc55369c1f0224237faf3</citedby><cites>FETCH-LOGICAL-c356t-7d58292ce3f8b2d72a8794e7fd789a21cdf4be043b4bdc55369c1f0224237faf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27900,27901</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31866221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dhir, Shalini</creatorcontrib><creatorcontrib>Dhir, Achal</creatorcontrib><title>Cardiovascular Risk Assessment for Noncardiac Surgery: Are We Ready for Biomarkers?</title><title>Journal of cardiothoracic and vascular anesthesia</title><addtitle>J Cardiothorac Vasc Anesth</addtitle><description>Biomarkers aided perioperative cardiac assessment is a relatively new concept. Cardiac biomarkers with historical significance (aspartate transaminase, dehydrogenase, creatinine kinase and myoglobin) have paved the way for traditional biomarkers (cardiac troponin, C-reactive protein, lipoprotein). Contemporary biomarkers like natriuretic peptides (BNP and ProBNP) are validated risk markers in both acute and chronic cardiac diseases and are showing remarkable promise in predicting serious cardiovascular complications after non-cardiac surgery. This review is intended to provide a critical overview of traditional and contemporary biomarkers for perioperative cardiovascular assessment and management. This review also discusses the potential utility of newer biomarkers like galectin-3, sST-2, GDF-15, TNF-alpha, MiRNAs and many others that can predict inflammation, cardiac remodeling, injury and endogenous stress and need further investigations to establish their clinical utility. Though promising, biomarker led perioperative care is still in infancy and it has not been determined that it can improve clinical outcomes.</description><subject>Biomarkers</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>cardiovascular system</subject><subject>Heart Disease Risk Factors</subject><subject>heart failure</subject><subject>Humans</subject><subject>Natriuretic Peptide, Brain</subject><subject>Peptide Fragments</subject><subject>perioperative care</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><issn>1053-0770</issn><issn>1532-8422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMotlb_gAfZo5et-dhsdkWQWvyCotAqHkM2mUj6tTXpFvrvzdrq0dMMwzMvMw9C5wT3CebsatqfbrTqU0zKOOhjkh2gLuGMpkVG6WHsI5ViIXAHnYQwxZgQzsUx6jBS5DmlpIsmQ-WNqzcq6GaufDJ2YZYMQoAQFrBcJ7b2yUu91C2ldDJp_Cf47XUy8JB8QDIGZbY_0J2rF8rPwIfbU3Rk1TzA2b720PvD_dvwKR29Pj4PB6NUM56vU2F4QUuqgdmiokZQVYgyA2GNKEpFiTY2qwBnrMoqozlneamJxZRmlAmrLOuhy13uytdfDYS1XLigYT5XS6ibICljGOc44yKidIdqX4fgwcqVd_HerSRYtprkVLYyZSuznUWZcelin99UCzB_K7_2InCzAyB-uXHgZdAOlhqM86DX0tTuv_xvoOaFNA</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Dhir, Shalini</creator><creator>Dhir, Achal</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202007</creationdate><title>Cardiovascular Risk Assessment for Noncardiac Surgery: Are We Ready for Biomarkers?</title><author>Dhir, Shalini ; Dhir, Achal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-7d58292ce3f8b2d72a8794e7fd789a21cdf4be043b4bdc55369c1f0224237faf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomarkers</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>cardiovascular system</topic><topic>Heart Disease Risk Factors</topic><topic>heart failure</topic><topic>Humans</topic><topic>Natriuretic Peptide, Brain</topic><topic>Peptide Fragments</topic><topic>perioperative care</topic><topic>Prognosis</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dhir, Shalini</creatorcontrib><creatorcontrib>Dhir, Achal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiothoracic and vascular anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dhir, Shalini</au><au>Dhir, Achal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular Risk Assessment for Noncardiac Surgery: Are We Ready for Biomarkers?</atitle><jtitle>Journal of cardiothoracic and vascular anesthesia</jtitle><addtitle>J Cardiothorac Vasc Anesth</addtitle><date>2020-07</date><risdate>2020</risdate><volume>34</volume><issue>7</issue><spage>1914</spage><epage>1924</epage><pages>1914-1924</pages><issn>1053-0770</issn><eissn>1532-8422</eissn><abstract>Biomarkers aided perioperative cardiac assessment is a relatively new concept. Cardiac biomarkers with historical significance (aspartate transaminase, dehydrogenase, creatinine kinase and myoglobin) have paved the way for traditional biomarkers (cardiac troponin, C-reactive protein, lipoprotein). Contemporary biomarkers like natriuretic peptides (BNP and ProBNP) are validated risk markers in both acute and chronic cardiac diseases and are showing remarkable promise in predicting serious cardiovascular complications after non-cardiac surgery. This review is intended to provide a critical overview of traditional and contemporary biomarkers for perioperative cardiovascular assessment and management. This review also discusses the potential utility of newer biomarkers like galectin-3, sST-2, GDF-15, TNF-alpha, MiRNAs and many others that can predict inflammation, cardiac remodeling, injury and endogenous stress and need further investigations to establish their clinical utility. Though promising, biomarker led perioperative care is still in infancy and it has not been determined that it can improve clinical outcomes.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31866221</pmid><doi>10.1053/j.jvca.2019.10.014</doi><tpages>11</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1053-0770
ispartof Journal of cardiothoracic and vascular anesthesia, 2020-07, Vol.34 (7), p.1914-1924
issn 1053-0770
1532-8422
language eng
recordid cdi_proquest_miscellaneous_2330060457
source ScienceDirect Freedom Collection 2022-2024
subjects Biomarkers
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
cardiovascular system
Heart Disease Risk Factors
heart failure
Humans
Natriuretic Peptide, Brain
Peptide Fragments
perioperative care
Prognosis
Risk Assessment
Risk Factors
title Cardiovascular Risk Assessment for Noncardiac Surgery: Are We Ready for Biomarkers?
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-24T12%3A37%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cardiovascular%20Risk%20Assessment%20for%20Noncardiac%20Surgery:%20Are%20We%20Ready%20for%20Biomarkers?&rft.jtitle=Journal%20of%20cardiothoracic%20and%20vascular%20anesthesia&rft.au=Dhir,%20Shalini&rft.date=2020-07&rft.volume=34&rft.issue=7&rft.spage=1914&rft.epage=1924&rft.pages=1914-1924&rft.issn=1053-0770&rft.eissn=1532-8422&rft_id=info:doi/10.1053/j.jvca.2019.10.014&rft_dat=%3Cproquest_cross%3E2330060457%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c356t-7d58292ce3f8b2d72a8794e7fd789a21cdf4be043b4bdc55369c1f0224237faf3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2330060457&rft_id=info:pmid/31866221&rfr_iscdi=true