Loading…
Cardiovascular Risk Assessment for Noncardiac Surgery: Are We Ready for Biomarkers?
Biomarkers aided perioperative cardiac assessment is a relatively new concept. Cardiac biomarkers with historical significance (aspartate transaminase, dehydrogenase, creatinine kinase and myoglobin) have paved the way for traditional biomarkers (cardiac troponin, C-reactive protein, lipoprotein). C...
Saved in:
Published in: | Journal of cardiothoracic and vascular anesthesia 2020-07, Vol.34 (7), p.1914-1924 |
---|---|
Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c356t-7d58292ce3f8b2d72a8794e7fd789a21cdf4be043b4bdc55369c1f0224237faf3 |
---|---|
cites | cdi_FETCH-LOGICAL-c356t-7d58292ce3f8b2d72a8794e7fd789a21cdf4be043b4bdc55369c1f0224237faf3 |
container_end_page | 1924 |
container_issue | 7 |
container_start_page | 1914 |
container_title | Journal of cardiothoracic and vascular anesthesia |
container_volume | 34 |
creator | Dhir, Shalini Dhir, Achal |
description | Biomarkers aided perioperative cardiac assessment is a relatively new concept. Cardiac biomarkers with historical significance (aspartate transaminase, dehydrogenase, creatinine kinase and myoglobin) have paved the way for traditional biomarkers (cardiac troponin, C-reactive protein, lipoprotein). Contemporary biomarkers like natriuretic peptides (BNP and ProBNP) are validated risk markers in both acute and chronic cardiac diseases and are showing remarkable promise in predicting serious cardiovascular complications after non-cardiac surgery. This review is intended to provide a critical overview of traditional and contemporary biomarkers for perioperative cardiovascular assessment and management. This review also discusses the potential utility of newer biomarkers like galectin-3, sST-2, GDF-15, TNF-alpha, MiRNAs and many others that can predict inflammation, cardiac remodeling, injury and endogenous stress and need further investigations to establish their clinical utility. Though promising, biomarker led perioperative care is still in infancy and it has not been determined that it can improve clinical outcomes. |
doi_str_mv | 10.1053/j.jvca.2019.10.014 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2330060457</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S105307701931047X</els_id><sourcerecordid>2330060457</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-7d58292ce3f8b2d72a8794e7fd789a21cdf4be043b4bdc55369c1f0224237faf3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotlb_gAfZo5et-dhsdkWQWvyCotAqHkM2mUj6tTXpFvrvzdrq0dMMwzMvMw9C5wT3CebsatqfbrTqU0zKOOhjkh2gLuGMpkVG6WHsI5ViIXAHnYQwxZgQzsUx6jBS5DmlpIsmQ-WNqzcq6GaufDJ2YZYMQoAQFrBcJ7b2yUu91C2ldDJp_Cf47XUy8JB8QDIGZbY_0J2rF8rPwIfbU3Rk1TzA2b720PvD_dvwKR29Pj4PB6NUM56vU2F4QUuqgdmiokZQVYgyA2GNKEpFiTY2qwBnrMoqozlneamJxZRmlAmrLOuhy13uytdfDYS1XLigYT5XS6ibICljGOc44yKidIdqX4fgwcqVd_HerSRYtprkVLYyZSuznUWZcelin99UCzB_K7_2InCzAyB-uXHgZdAOlhqM86DX0tTuv_xvoOaFNA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2330060457</pqid></control><display><type>article</type><title>Cardiovascular Risk Assessment for Noncardiac Surgery: Are We Ready for Biomarkers?</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Dhir, Shalini ; Dhir, Achal</creator><creatorcontrib>Dhir, Shalini ; Dhir, Achal</creatorcontrib><description>Biomarkers aided perioperative cardiac assessment is a relatively new concept. Cardiac biomarkers with historical significance (aspartate transaminase, dehydrogenase, creatinine kinase and myoglobin) have paved the way for traditional biomarkers (cardiac troponin, C-reactive protein, lipoprotein). Contemporary biomarkers like natriuretic peptides (BNP and ProBNP) are validated risk markers in both acute and chronic cardiac diseases and are showing remarkable promise in predicting serious cardiovascular complications after non-cardiac surgery. This review is intended to provide a critical overview of traditional and contemporary biomarkers for perioperative cardiovascular assessment and management. This review also discusses the potential utility of newer biomarkers like galectin-3, sST-2, GDF-15, TNF-alpha, MiRNAs and many others that can predict inflammation, cardiac remodeling, injury and endogenous stress and need further investigations to establish their clinical utility. Though promising, biomarker led perioperative care is still in infancy and it has not been determined that it can improve clinical outcomes.</description><identifier>ISSN: 1053-0770</identifier><identifier>EISSN: 1532-8422</identifier><identifier>DOI: 10.1053/j.jvca.2019.10.014</identifier><identifier>PMID: 31866221</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Biomarkers ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; cardiovascular system ; Heart Disease Risk Factors ; heart failure ; Humans ; Natriuretic Peptide, Brain ; Peptide Fragments ; perioperative care ; Prognosis ; Risk Assessment ; Risk Factors</subject><ispartof>Journal of cardiothoracic and vascular anesthesia, 2020-07, Vol.34 (7), p.1914-1924</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-7d58292ce3f8b2d72a8794e7fd789a21cdf4be043b4bdc55369c1f0224237faf3</citedby><cites>FETCH-LOGICAL-c356t-7d58292ce3f8b2d72a8794e7fd789a21cdf4be043b4bdc55369c1f0224237faf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27900,27901</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31866221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dhir, Shalini</creatorcontrib><creatorcontrib>Dhir, Achal</creatorcontrib><title>Cardiovascular Risk Assessment for Noncardiac Surgery: Are We Ready for Biomarkers?</title><title>Journal of cardiothoracic and vascular anesthesia</title><addtitle>J Cardiothorac Vasc Anesth</addtitle><description>Biomarkers aided perioperative cardiac assessment is a relatively new concept. Cardiac biomarkers with historical significance (aspartate transaminase, dehydrogenase, creatinine kinase and myoglobin) have paved the way for traditional biomarkers (cardiac troponin, C-reactive protein, lipoprotein). Contemporary biomarkers like natriuretic peptides (BNP and ProBNP) are validated risk markers in both acute and chronic cardiac diseases and are showing remarkable promise in predicting serious cardiovascular complications after non-cardiac surgery. This review is intended to provide a critical overview of traditional and contemporary biomarkers for perioperative cardiovascular assessment and management. This review also discusses the potential utility of newer biomarkers like galectin-3, sST-2, GDF-15, TNF-alpha, MiRNAs and many others that can predict inflammation, cardiac remodeling, injury and endogenous stress and need further investigations to establish their clinical utility. Though promising, biomarker led perioperative care is still in infancy and it has not been determined that it can improve clinical outcomes.</description><subject>Biomarkers</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>cardiovascular system</subject><subject>Heart Disease Risk Factors</subject><subject>heart failure</subject><subject>Humans</subject><subject>Natriuretic Peptide, Brain</subject><subject>Peptide Fragments</subject><subject>perioperative care</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><issn>1053-0770</issn><issn>1532-8422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMotlb_gAfZo5et-dhsdkWQWvyCotAqHkM2mUj6tTXpFvrvzdrq0dMMwzMvMw9C5wT3CebsatqfbrTqU0zKOOhjkh2gLuGMpkVG6WHsI5ViIXAHnYQwxZgQzsUx6jBS5DmlpIsmQ-WNqzcq6GaufDJ2YZYMQoAQFrBcJ7b2yUu91C2ldDJp_Cf47XUy8JB8QDIGZbY_0J2rF8rPwIfbU3Rk1TzA2b720PvD_dvwKR29Pj4PB6NUM56vU2F4QUuqgdmiokZQVYgyA2GNKEpFiTY2qwBnrMoqozlneamJxZRmlAmrLOuhy13uytdfDYS1XLigYT5XS6ibICljGOc44yKidIdqX4fgwcqVd_HerSRYtprkVLYyZSuznUWZcelin99UCzB_K7_2InCzAyB-uXHgZdAOlhqM86DX0tTuv_xvoOaFNA</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Dhir, Shalini</creator><creator>Dhir, Achal</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202007</creationdate><title>Cardiovascular Risk Assessment for Noncardiac Surgery: Are We Ready for Biomarkers?</title><author>Dhir, Shalini ; Dhir, Achal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-7d58292ce3f8b2d72a8794e7fd789a21cdf4be043b4bdc55369c1f0224237faf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomarkers</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>cardiovascular system</topic><topic>Heart Disease Risk Factors</topic><topic>heart failure</topic><topic>Humans</topic><topic>Natriuretic Peptide, Brain</topic><topic>Peptide Fragments</topic><topic>perioperative care</topic><topic>Prognosis</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dhir, Shalini</creatorcontrib><creatorcontrib>Dhir, Achal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiothoracic and vascular anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dhir, Shalini</au><au>Dhir, Achal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular Risk Assessment for Noncardiac Surgery: Are We Ready for Biomarkers?</atitle><jtitle>Journal of cardiothoracic and vascular anesthesia</jtitle><addtitle>J Cardiothorac Vasc Anesth</addtitle><date>2020-07</date><risdate>2020</risdate><volume>34</volume><issue>7</issue><spage>1914</spage><epage>1924</epage><pages>1914-1924</pages><issn>1053-0770</issn><eissn>1532-8422</eissn><abstract>Biomarkers aided perioperative cardiac assessment is a relatively new concept. Cardiac biomarkers with historical significance (aspartate transaminase, dehydrogenase, creatinine kinase and myoglobin) have paved the way for traditional biomarkers (cardiac troponin, C-reactive protein, lipoprotein). Contemporary biomarkers like natriuretic peptides (BNP and ProBNP) are validated risk markers in both acute and chronic cardiac diseases and are showing remarkable promise in predicting serious cardiovascular complications after non-cardiac surgery. This review is intended to provide a critical overview of traditional and contemporary biomarkers for perioperative cardiovascular assessment and management. This review also discusses the potential utility of newer biomarkers like galectin-3, sST-2, GDF-15, TNF-alpha, MiRNAs and many others that can predict inflammation, cardiac remodeling, injury and endogenous stress and need further investigations to establish their clinical utility. Though promising, biomarker led perioperative care is still in infancy and it has not been determined that it can improve clinical outcomes.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31866221</pmid><doi>10.1053/j.jvca.2019.10.014</doi><tpages>11</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1053-0770 |
ispartof | Journal of cardiothoracic and vascular anesthesia, 2020-07, Vol.34 (7), p.1914-1924 |
issn | 1053-0770 1532-8422 |
language | eng |
recordid | cdi_proquest_miscellaneous_2330060457 |
source | ScienceDirect Freedom Collection 2022-2024 |
subjects | Biomarkers Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology cardiovascular system Heart Disease Risk Factors heart failure Humans Natriuretic Peptide, Brain Peptide Fragments perioperative care Prognosis Risk Assessment Risk Factors |
title | Cardiovascular Risk Assessment for Noncardiac Surgery: Are We Ready for Biomarkers? |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-24T12%3A37%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cardiovascular%20Risk%20Assessment%20for%20Noncardiac%20Surgery:%20Are%20We%20Ready%20for%20Biomarkers?&rft.jtitle=Journal%20of%20cardiothoracic%20and%20vascular%20anesthesia&rft.au=Dhir,%20Shalini&rft.date=2020-07&rft.volume=34&rft.issue=7&rft.spage=1914&rft.epage=1924&rft.pages=1914-1924&rft.issn=1053-0770&rft.eissn=1532-8422&rft_id=info:doi/10.1053/j.jvca.2019.10.014&rft_dat=%3Cproquest_cross%3E2330060457%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c356t-7d58292ce3f8b2d72a8794e7fd789a21cdf4be043b4bdc55369c1f0224237faf3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2330060457&rft_id=info:pmid/31866221&rfr_iscdi=true |