Vitamin D status of untreated children and adolescent Egyptian patients with genetic generalized epilepsy: A case–control study

Antiepileptic drugs (AEDs) are commonly incriminated for vitamin D deficiency in children with epilepsy. The aim of this study was to examine 25(OH) vitamin D status among children and adolescents with genetic generalized epilepsy (GGE) who had never received AEDs and its relation to seizure frequen...

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Bibliographic Details
Published in:Epilepsy & behavior 2020-02, Vol.103 (Pt A), p.106840-106840, Article 106840
Main Authors: Elmazny, Alaa, Amer, Hanan, Rashed, Laila, Khalil, Sarah, Magdy, Rehab
Format: Article
Language:English
Subjects:
Genetic generalized epilepsy
Treatment-naive
Vitamin D
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Summary:Antiepileptic drugs (AEDs) are commonly incriminated for vitamin D deficiency in children with epilepsy. The aim of this study was to examine 25(OH) vitamin D status among children and adolescents with genetic generalized epilepsy (GGE) who had never received AEDs and its relation to seizure frequency and epilepsy duration. This case–control study was conducted on 42 recently diagnosed patients with GGE, aged ≤18 years and 40 age- and gender-matched controls. Serum 25(OH) vitamin D level was performed for all participants. Serum 25(OH) vitamin D level was significantly lower in patients (median = 22 ng/ml, interquartile range (IQR) = 16.6–28.6) compared with controls (median = 58.4 ng/ml, IQR = 53–68), (P-value 
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2019.106840