Hemoadsorption by extracorporeal cytokine adsorption therapy (CytoSorb®) in the management of septic shock: A retrospective observational study

• Published in: International journal of artificial organs 2020-06, Vol.43 (6), p.372-378
• Main Authors: Singh, YP, Chhabra, SC, Lashkari, K, Taneja, A, Garg, A, Chandra, A, Chhabra, M, Singh, GP, Jain, S
• Format: Article
• Language: English
• Subjects: Adsorption; Adult; Aged; Cytokines; Cytokines - blood; Detoxification; Female; Hemoperfusion - methods; Humans; Inflammation; Leukocytes; Male; Medical research; Middle Aged; Observational studies; Organ Dysfunction Scores; Patients; Procalcitonin; Retrospective Studies; Schedules; Sepsis; Septic shock; Shock, Septic - blood; Shock, Septic - therapy; Statistical analysis; Therapy; Treatment Outcome
• ISSN: 0391-3988; 1724-6040
• DOI: 10.1177/0391398819891739

Introduction: Sepsis results in immunologic disturbances with the release of various inflammatory mediators such as cytokines. Cytokines can damage the cells, and the continuous release of inflammatory mediators leads to severely impaired immunity. Therefore, the reduction in cytokine levels by hemoadsorption represents a new concept for blood purification. CytoSorb® as a hemoadsorption device is a detoxification system, which aims to decrease the cytokines levels. This study was conducted to understand any beneficial effects of CytoSorb® therapy in septic patients. Methodology: This was a retrospective and observational study, approved by the scientific and ethics committee of Max Super Specialty Hospital, Patparganj, Delhi, India and conducted in compliance with current International Council for Harmonization, Good Clinical Practice, Schedule Y, and Indian Council of Medical Research guidelines. Subjects of either gender (age > 18 year) were included in the study. The data were presented as mean ± standard deviation and categorical as frequency and percentage (%). A p value less than 0.05 (p