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Frailty and coronary plaque characteristics on optical coherence tomography
The relationship between frailty and plaque characteristics is unclear and was investigated by optical coherence tomography (OCT) in this study. One hundred and four patients undergoing OCT before percutaneous coronary intervention were evaluated. Frailty was defined as a clinical frailty scale scor...
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| Published in: | Heart and vessels 2020-06, Vol.35 (6), p.750-761 |
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| container_end_page | 761 |
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| container_start_page | 750 |
| container_title | Heart and vessels |
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| creator | Amano, Hideo Noike, Ryota Yabe, Takayuki Watanabe, Ippei Okubo, Ryo Koizumi, Masayuki Toda, Mikihito Ikeda, Takanori |
| description | The relationship between frailty and plaque characteristics is unclear and was investigated by optical coherence tomography (OCT) in this study. One hundred and four patients undergoing OCT before percutaneous coronary intervention were evaluated. Frailty was defined as a clinical frailty scale score of ≧6. Frailty was found in 16% of the patients (17/104). Compared with the nonfrail patients, frail patients showed significantly lower body mass index (BMI; 20.8 ± 4.0 kg/m
2
vs. 25.0 ± 3.9 kg/m
2
,
P
|
| doi_str_mv | 10.1007/s00380-019-01547-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2330063322</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2398225355</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-9dd4434ba55332c15974883cac71de92e5f7caa11ae4405cb2cd455ac321c8a53</originalsourceid><addsrcrecordid>eNp9kLtOwzAUQC0EoqXwAwwoEgtLwM88RlRRQFRigdm6vXHbVEkc7GTo3-OQAhIDg2VLPj6-OoRcMnrLKE3vPKUiozFleVhKpjE_IlOWMBVzlYpjMqU5o3EmeDohZ97vaKBylp-SiWBZoqTgU_KycFBW3T6CpojQOtuA20dtBR-9iXALDrAzrvRdiT6yTWTbcIIqoFvjTIMm6mxtNw7a7f6cnKyh8ubisM_I--Lhbf4UL18fn-f3yxhloro4LwophVyBUkJwDDOlMssEAqasMDk3ap0iAGNgpKQKVxwLqRSg4AwzUGJGbkZv62wY03e6Lj2aqoLG2N5rLgSlSXDzgF7_QXe2d02YLlB5xrkSahDykUJnvXdmrVtX1iGEZlQPqfWYWofU-iu1HtRXB3W_qk3x8-S7bQDECPhw1WyM-_37H-0n9ayJJg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2398225355</pqid></control><display><type>article</type><title>Frailty and coronary plaque characteristics on optical coherence tomography</title><source>Springer Nature</source><creator>Amano, Hideo ; Noike, Ryota ; Yabe, Takayuki ; Watanabe, Ippei ; Okubo, Ryo ; Koizumi, Masayuki ; Toda, Mikihito ; Ikeda, Takanori</creator><creatorcontrib>Amano, Hideo ; Noike, Ryota ; Yabe, Takayuki ; Watanabe, Ippei ; Okubo, Ryo ; Koizumi, Masayuki ; Toda, Mikihito ; Ikeda, Takanori</creatorcontrib><description>The relationship between frailty and plaque characteristics is unclear and was investigated by optical coherence tomography (OCT) in this study. One hundred and four patients undergoing OCT before percutaneous coronary intervention were evaluated. Frailty was defined as a clinical frailty scale score of ≧6. Frailty was found in 16% of the patients (17/104). Compared with the nonfrail patients, frail patients showed significantly lower body mass index (BMI; 20.8 ± 4.0 kg/m
2
vs. 25.0 ± 3.9 kg/m
2
,
P
< 0.001), less dyslipidemia [47% (8/17) vs. 75% (65/87),
P
= 0.023], lower triglycerides levels (95 ± 42 mg/dL vs. 147 ± 81 mg/dL,
P
< 0.001), less use of statin [29% (5/17) vs. 60% (52/87),
P
= 0.021], more lipid-rich plaque [82% (14/17) vs. 46% (40/87),
P
= 0.006] on OCT, more thin-cap fibroatheromas [TCFAs; 71% (12/17) vs. 26% (23/87),
P
< 0.001], more plaque rupture [53% (9/17) vs. 25% (22/87),
P
= 0.023], and significantly higher adverse clinical outcomes (death, acute myocardial infarction, acute heart failure, acute coronary syndrome, or target lesion revascularization) [24% (4/17) vs. 6% (5/87),
P
= 0.007]. The multivariable analysis showed that frailty was one of the independent predictors of TCFAs (odds ratio 8.95, 95% CI 2.40–33.32,
P
= 0.001). In conclusion, frailty was associated with high plaque vulnerability due to more lipid-rich plaque, TCFAs and plaque rupture on OCT regardless of low BMI, less dyslipidemia and low triglycerides levels, and frail patients had higher adverse clinical outcomes.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-019-01547-2</identifier><identifier>PMID: 31865432</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Aged ; Aged, 80 and over ; Biomedical Engineering and Bioengineering ; Body mass ; Body mass index ; Body size ; Cardiac Surgery ; Cardiology ; Clinical outcomes ; Congestive heart failure ; Coronary Artery Disease - complications ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - therapy ; Coronary Stenosis - complications ; Coronary Stenosis - diagnostic imaging ; Coronary Stenosis - therapy ; Coronary Vessels - diagnostic imaging ; Dyslipidemia ; Female ; Frailty ; Frailty - complications ; Frailty - diagnosis ; Functional Status ; Geriatric Assessment ; Heart Disease Risk Factors ; Humans ; Lipids ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Myocardial infarction ; Optical Coherence Tomography ; Original Article ; Percutaneous Coronary Intervention ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Risk Assessment ; Rupture ; Rupture, Spontaneous ; Tomography ; Tomography, Optical Coherence ; Triglycerides ; Vascular Surgery</subject><ispartof>Heart and vessels, 2020-06, Vol.35 (6), p.750-761</ispartof><rights>Springer Japan KK, part of Springer Nature 2019</rights><rights>Springer Japan KK, part of Springer Nature 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-9dd4434ba55332c15974883cac71de92e5f7caa11ae4405cb2cd455ac321c8a53</citedby><cites>FETCH-LOGICAL-c465t-9dd4434ba55332c15974883cac71de92e5f7caa11ae4405cb2cd455ac321c8a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31865432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amano, Hideo</creatorcontrib><creatorcontrib>Noike, Ryota</creatorcontrib><creatorcontrib>Yabe, Takayuki</creatorcontrib><creatorcontrib>Watanabe, Ippei</creatorcontrib><creatorcontrib>Okubo, Ryo</creatorcontrib><creatorcontrib>Koizumi, Masayuki</creatorcontrib><creatorcontrib>Toda, Mikihito</creatorcontrib><creatorcontrib>Ikeda, Takanori</creatorcontrib><title>Frailty and coronary plaque characteristics on optical coherence tomography</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>The relationship between frailty and plaque characteristics is unclear and was investigated by optical coherence tomography (OCT) in this study. One hundred and four patients undergoing OCT before percutaneous coronary intervention were evaluated. Frailty was defined as a clinical frailty scale score of ≧6. Frailty was found in 16% of the patients (17/104). Compared with the nonfrail patients, frail patients showed significantly lower body mass index (BMI; 20.8 ± 4.0 kg/m
2
vs. 25.0 ± 3.9 kg/m
2
,
P
< 0.001), less dyslipidemia [47% (8/17) vs. 75% (65/87),
P
= 0.023], lower triglycerides levels (95 ± 42 mg/dL vs. 147 ± 81 mg/dL,
P
< 0.001), less use of statin [29% (5/17) vs. 60% (52/87),
P
= 0.021], more lipid-rich plaque [82% (14/17) vs. 46% (40/87),
P
= 0.006] on OCT, more thin-cap fibroatheromas [TCFAs; 71% (12/17) vs. 26% (23/87),
P
< 0.001], more plaque rupture [53% (9/17) vs. 25% (22/87),
P
= 0.023], and significantly higher adverse clinical outcomes (death, acute myocardial infarction, acute heart failure, acute coronary syndrome, or target lesion revascularization) [24% (4/17) vs. 6% (5/87),
P
= 0.007]. The multivariable analysis showed that frailty was one of the independent predictors of TCFAs (odds ratio 8.95, 95% CI 2.40–33.32,
P
= 0.001). In conclusion, frailty was associated with high plaque vulnerability due to more lipid-rich plaque, TCFAs and plaque rupture on OCT regardless of low BMI, less dyslipidemia and low triglycerides levels, and frail patients had higher adverse clinical outcomes.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Clinical outcomes</subject><subject>Congestive heart failure</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - therapy</subject><subject>Coronary Stenosis - complications</subject><subject>Coronary Stenosis - diagnostic imaging</subject><subject>Coronary Stenosis - therapy</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Dyslipidemia</subject><subject>Female</subject><subject>Frailty</subject><subject>Frailty - complications</subject><subject>Frailty - diagnosis</subject><subject>Functional Status</subject><subject>Geriatric Assessment</subject><subject>Heart Disease Risk Factors</subject><subject>Humans</subject><subject>Lipids</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Myocardial infarction</subject><subject>Optical Coherence Tomography</subject><subject>Original Article</subject><subject>Percutaneous Coronary Intervention</subject><subject>Plaque, Atherosclerotic</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Rupture</subject><subject>Rupture, Spontaneous</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence</subject><subject>Triglycerides</subject><subject>Vascular Surgery</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kLtOwzAUQC0EoqXwAwwoEgtLwM88RlRRQFRigdm6vXHbVEkc7GTo3-OQAhIDg2VLPj6-OoRcMnrLKE3vPKUiozFleVhKpjE_IlOWMBVzlYpjMqU5o3EmeDohZ97vaKBylp-SiWBZoqTgU_KycFBW3T6CpojQOtuA20dtBR-9iXALDrAzrvRdiT6yTWTbcIIqoFvjTIMm6mxtNw7a7f6cnKyh8ubisM_I--Lhbf4UL18fn-f3yxhloro4LwophVyBUkJwDDOlMssEAqasMDk3ap0iAGNgpKQKVxwLqRSg4AwzUGJGbkZv62wY03e6Lj2aqoLG2N5rLgSlSXDzgF7_QXe2d02YLlB5xrkSahDykUJnvXdmrVtX1iGEZlQPqfWYWofU-iu1HtRXB3W_qk3x8-S7bQDECPhw1WyM-_37H-0n9ayJJg</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Amano, Hideo</creator><creator>Noike, Ryota</creator><creator>Yabe, Takayuki</creator><creator>Watanabe, Ippei</creator><creator>Okubo, Ryo</creator><creator>Koizumi, Masayuki</creator><creator>Toda, Mikihito</creator><creator>Ikeda, Takanori</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20200601</creationdate><title>Frailty and coronary plaque characteristics on optical coherence tomography</title><author>Amano, Hideo ; Noike, Ryota ; Yabe, Takayuki ; Watanabe, Ippei ; Okubo, Ryo ; Koizumi, Masayuki ; Toda, Mikihito ; Ikeda, Takanori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-9dd4434ba55332c15974883cac71de92e5f7caa11ae4405cb2cd455ac321c8a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Clinical outcomes</topic><topic>Congestive heart failure</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - therapy</topic><topic>Coronary Stenosis - complications</topic><topic>Coronary Stenosis - diagnostic imaging</topic><topic>Coronary Stenosis - therapy</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Dyslipidemia</topic><topic>Female</topic><topic>Frailty</topic><topic>Frailty - complications</topic><topic>Frailty - diagnosis</topic><topic>Functional Status</topic><topic>Geriatric Assessment</topic><topic>Heart Disease Risk Factors</topic><topic>Humans</topic><topic>Lipids</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Myocardial infarction</topic><topic>Optical Coherence Tomography</topic><topic>Original Article</topic><topic>Percutaneous Coronary Intervention</topic><topic>Plaque, Atherosclerotic</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Rupture</topic><topic>Rupture, Spontaneous</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence</topic><topic>Triglycerides</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amano, Hideo</creatorcontrib><creatorcontrib>Noike, Ryota</creatorcontrib><creatorcontrib>Yabe, Takayuki</creatorcontrib><creatorcontrib>Watanabe, Ippei</creatorcontrib><creatorcontrib>Okubo, Ryo</creatorcontrib><creatorcontrib>Koizumi, Masayuki</creatorcontrib><creatorcontrib>Toda, Mikihito</creatorcontrib><creatorcontrib>Ikeda, Takanori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amano, Hideo</au><au>Noike, Ryota</au><au>Yabe, Takayuki</au><au>Watanabe, Ippei</au><au>Okubo, Ryo</au><au>Koizumi, Masayuki</au><au>Toda, Mikihito</au><au>Ikeda, Takanori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frailty and coronary plaque characteristics on optical coherence tomography</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>35</volume><issue>6</issue><spage>750</spage><epage>761</epage><pages>750-761</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><abstract>The relationship between frailty and plaque characteristics is unclear and was investigated by optical coherence tomography (OCT) in this study. One hundred and four patients undergoing OCT before percutaneous coronary intervention were evaluated. Frailty was defined as a clinical frailty scale score of ≧6. Frailty was found in 16% of the patients (17/104). Compared with the nonfrail patients, frail patients showed significantly lower body mass index (BMI; 20.8 ± 4.0 kg/m
2
vs. 25.0 ± 3.9 kg/m
2
,
P
< 0.001), less dyslipidemia [47% (8/17) vs. 75% (65/87),
P
= 0.023], lower triglycerides levels (95 ± 42 mg/dL vs. 147 ± 81 mg/dL,
P
< 0.001), less use of statin [29% (5/17) vs. 60% (52/87),
P
= 0.021], more lipid-rich plaque [82% (14/17) vs. 46% (40/87),
P
= 0.006] on OCT, more thin-cap fibroatheromas [TCFAs; 71% (12/17) vs. 26% (23/87),
P
< 0.001], more plaque rupture [53% (9/17) vs. 25% (22/87),
P
= 0.023], and significantly higher adverse clinical outcomes (death, acute myocardial infarction, acute heart failure, acute coronary syndrome, or target lesion revascularization) [24% (4/17) vs. 6% (5/87),
P
= 0.007]. The multivariable analysis showed that frailty was one of the independent predictors of TCFAs (odds ratio 8.95, 95% CI 2.40–33.32,
P
= 0.001). In conclusion, frailty was associated with high plaque vulnerability due to more lipid-rich plaque, TCFAs and plaque rupture on OCT regardless of low BMI, less dyslipidemia and low triglycerides levels, and frail patients had higher adverse clinical outcomes.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>31865432</pmid><doi>10.1007/s00380-019-01547-2</doi><tpages>12</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Biomedical Engineering and Bioengineering Body mass Body mass index Body size Cardiac Surgery Cardiology Clinical outcomes Congestive heart failure Coronary Artery Disease - complications Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - therapy Coronary Stenosis - complications Coronary Stenosis - diagnostic imaging Coronary Stenosis - therapy Coronary Vessels - diagnostic imaging Dyslipidemia Female Frailty Frailty - complications Frailty - diagnosis Functional Status Geriatric Assessment Heart Disease Risk Factors Humans Lipids Male Medicine Medicine & Public Health Middle Aged Myocardial infarction Optical Coherence Tomography Original Article Percutaneous Coronary Intervention Plaque, Atherosclerotic Predictive Value of Tests Prognosis Retrospective Studies Risk Assessment Rupture Rupture, Spontaneous Tomography Tomography, Optical Coherence Triglycerides Vascular Surgery |
| title | Frailty and coronary plaque characteristics on optical coherence tomography |
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