Preoperative biopsy and tumor recurrence of stage I adenocarcinoma of the lung

Purpose To evaluate whether preoperative biopsy affects the outcomes of patients undergoing at least lobectomy for stage I lung adenocarcinoma. Methods We reviewed the medical records of patients who underwent surgery for stage I lung adenocarcinoma between 2006 and 2013. Tumor recurrence and surviv...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2020-07, Vol.50 (7), p.673-684
Main Authors: Huang, Chien-Sheng, Hsu, Po-Kuei, Chen, Chun-Ku, Yeh, Yi-Chen, Chen, Hui-Shan, Wu, Mei-Han, Chou, Teh-Ying, Hsu, Wen-Hu, Shih, Chun-Che, Huang, Biing-Shiun
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Original Article
Surgery
Surgical Oncology
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Summary:Purpose To evaluate whether preoperative biopsy affects the outcomes of patients undergoing at least lobectomy for stage I lung adenocarcinoma. Methods We reviewed the medical records of patients who underwent surgery for stage I lung adenocarcinoma between 2006 and 2013. Tumor recurrence and survival were compared between patients who underwent preoperative biopsy, including computed tomographic-guided needle biopsy and transbronchial biopsy, and those who underwent intraoperative frozen section. Results Among 509 patients, 229 patients (44.9%) underwent preoperative biopsy and 280 patients had lung adenocarcinoma diagnosed by intraoperative frozen section (reference group). Recurrence developed in 65 (12.8%) patients within a median follow-up period of 54.4 months. Multivariate analysis demonstrated that preoperative biopsy (OR 1.97, p  = 0.045), radiological solid appearance (OR 5.43, p  
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-019-01941-3