Metabolic profiling of acromegaly using a GC–MS-based nontargeted metabolomic approach

Purpose Acromegaly is a rare disease caused by chronic hypersecretion of growth hormone, which leads to multiple comorbidities and reduced life expectancy. The objective of this study was to characterize the serum metabolic profiles of acromegaly patients and identify metabolic biomarkers using meta...

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Bibliographic Details
Published in:Endocrine 2020-02, Vol.67 (2), p.433-441
Main Authors: Yu, Hengchi, Zhao, Yaqun, Zhang, Yazhuo, Zhong, Liyong
Format: Article
Language:English
Subjects:
Acids
Acromegaly
Aspartic acid
Biomarkers
Diabetes
Dithiothreitol
Endocrinology
Gas chromatography
Gluconic acid
Glutamic acid
Growth hormones
Humanities and Social Sciences
Internal Medicine
Life span
Mass spectroscopy
Medicine
Medicine & Public Health
Metabolic pathways
Metabolism
Metabolites
Metabolomics
multidisciplinary
N-Acetyl-L-glutamic acid
Original Article
Pentose phosphate pathway
Rare diseases
Science
Serum levels
Statistical analysis
Taurine
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Summary:Purpose Acromegaly is a rare disease caused by chronic hypersecretion of growth hormone, which leads to multiple comorbidities and reduced life expectancy. The objective of this study was to characterize the serum metabolic profiles of acromegaly patients and identify metabolic biomarkers using metabolomics. Methods Twenty-nine active acromegaly patients and age- and sex-matched normal controls were recruited. Serum samples were collected, and serum metabolites were analyzed using gas chromatography–mass spectrometry coupled with a series of multivariate statistical analyses. Results The orthogonal projections to latent structures-discriminate analysis (OPLS-DA) model identified and validated significant metabolic differences between individuals with acromegaly and normal controls ( R 2 Y  = 0.908 and Q 2 Y  = 0.601). Compared with normal controls, acromegaly patients had elevated levels of 5-aminovaleric acid, glyceric acid, l -dithiothreitol, dihydrocoumarin, N-acetyl-L-glutamic acid, gluconic acid, and monoolein ( P  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-019-02143-0