Inhibition of vertebrate aldehyde oxidase as a therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis

The aldehyde oxidases (AOXs) are a small sub-family of cytosolic molybdo-flavoenzymes, which are structurally conserved proteins and broadly distributed from plants to animals. AOXs play multiple roles in both physiological and pathological processes and AOX inhibition is of increasing significance...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2020-02, Vol.187, p.111948-111948, Article 111948
Main Authors: Qiao, Yixue, Maiti, Kaushik, Sultana, Zakia, Fu, Lei, Smith, Roger
Format: Article
Language:English
Subjects:
Aldehyde oxidase
Aldehyde Oxidase - antagonists & inhibitors
Aldehyde Oxidase - metabolism
Amyotrophic Lateral Sclerosis - drug therapy
Amyotrophic Lateral Sclerosis - metabolism
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
AOX inhibition
Drug metabolism
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Evolution
Humans
Neoplasms - drug therapy
Neoplasms - metabolism
Neuroprotective Agents - chemistry
Neuroprotective Agents - pharmacology
Obesity - drug therapy
Obesity - metabolism
Physiology
Polymorphism
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Summary:The aldehyde oxidases (AOXs) are a small sub-family of cytosolic molybdo-flavoenzymes, which are structurally conserved proteins and broadly distributed from plants to animals. AOXs play multiple roles in both physiological and pathological processes and AOX inhibition is of increasing significance in the development of novel drugs and therapeutic strategies. This review provides an overview of the evolution and the action mechanism of AOX and the role of each domain. The review provides an update of the polymorphisms in the human AOX. This review also summarises the physiology of AOX in different organs and its role in drug metabolism. The inhibition of AOX is a promising therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis. [Display omitted] •This review described the evolution of AOX.•This review summarised the structure of AOX and its role in drug metabolism.•This review provided an update of the polymorphisms in the human AOX.•AOXs play physiological roles in multiple tissues.•The inhibition of AOX is a promising therapy for cancer, obesity, aging and ALS.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2019.111948