Late locoregional complications associated with adjuvant radiotherapy in the treatment of breast cancer: Systematic review and meta‐analysis

This systematic review with meta‐analysis addressed late locoregional complications associated with adjuvant radiotherapy (RT) in breast cancer. Among 2120 titles, ten comparative studies in patients undergoing surgery vs surgery and radiotherapy reporting complications were evaluated. RT was associ...

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Bibliographic Details
Published in:Journal of surgical oncology 2020-04, Vol.121 (5), p.766-776
Main Authors: Kanda, Márcia Helena, Costa Vieira, René Aloisio, Lima, João Paulo S. N., Paiva, Carlos Eduardo, Araujo, Raphael Leonardo Cunha
Format: Article
Language:English
Subjects:
Breast cancer
Breast Neoplasms - therapy
complications
Contracture - etiology
Female
Humans
Lymphedema
Lymphedema - etiology
Mastectomy
Meta-analysis
Radiation therapy
radiotherapy
Radiotherapy, Adjuvant - adverse effects
Side effects
Systematic review
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Summary:This systematic review with meta‐analysis addressed late locoregional complications associated with adjuvant radiotherapy (RT) in breast cancer. Among 2120 titles, ten comparative studies in patients undergoing surgery vs surgery and radiotherapy reporting complications were evaluated. RT was associated with an increased risk of capsular contracture and decreased the mobility of the upper limb. A borderline association of lymphedema risk using RT was noted in the random‐effects model but was significant in the fixed‐effects model.
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.25820