Adaptive tracking of enzymatic reactions with quantum light

Enzymes are essential to maintain organisms alive. Some of the reactions they catalyze are associated with a change in reagents chirality, hence their activity can be tracked by using optical means. However, illumination affects enzyme activity: the challenge is to operate at low-intensity regime av...

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Bibliographic Details
Published in:Optics express 2019-11, Vol.27 (24), p.35245-35256
Main Authors: Cimini, Valeria, Mellini, Marta, Rampioni, Giordano, Sbroscia, Marco, Leoni, Livia, Barbieri, Marco, Gianani, Ilaria
Format: Article
Language:English
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Summary:Enzymes are essential to maintain organisms alive. Some of the reactions they catalyze are associated with a change in reagents chirality, hence their activity can be tracked by using optical means. However, illumination affects enzyme activity: the challenge is to operate at low-intensity regime avoiding loss in sensitivity. Here we apply quantum phase estimation to real-time measurement of invertase enzymatic activity. Control of the probe at the quantum level demonstrates the potential for reducing invasiveness with optimized sensitivity at once. This preliminary effort, bringing together methods of quantum physics and biology, constitutes an important step towards full development of quantum sensors for biological systems.
ISSN:1094-4087
1094-4087
DOI:10.1364/OE.27.035245