Abnormal brain gamma oscillations in response to auditory stimulation in Dravet syndrome

• Published in: European journal of paediatric neurology 2020-01, Vol.24, p.134-141
• Main Authors: Sanchez-Carpintero, Rocio, Urrestarazu, Elena, Cieza, Sofía, Alegre, Manuel, Artieda, Julio, Crespo-Eguilaz, Nerea, Valencia, Miguel
• Format: Article
• Language: English
• Subjects: Auditory evoked potentials; Dravet syndrome; Epileptic encephalopathy; Inhibitory interneurons; Oscillatory gamma activity
• ISSN: 1090-3798; 1532-2130
• DOI: 10.1016/j.ejpn.2019.12.004

To evaluate the capability of children with Dravet syndrome to generate brain γ-oscillatory activity in response to auditory steady-state stimulation. Fifty-one subjects were included: 13 with Dravet syndrome with SCN1A gene alterations, 26 with non-Dravet epilepsies and 12 healthy controls. Responses to auditory steady-state stimulation elicited with a chirp-modulated tone between 1 and 120 Hz were collected in subjects and compared across groups. Subjects with Dravet syndrome showed weak or no responses in the 1–120 Hz frequency range. Healthy controls showed oscillatory responses following the frequency of the modulation that were maximal in the low (30–70 Hz) and high (80–120) γ-ranges both, in the power and inter-trial coherence estimates. Non-Dravet epileptic children showed differences in the auditory responses when compared with the healthy controls but were able to generate oscillatory evoked activities following the frequency-varying stimulation. The ability to generate brain γ-oscillatory activity of children with Dravet in response to a chirp-modulated auditory stimulus is highly impaired, is not due to epilepsy and is consistent with the Nav1.1 channel dysfunction affecting interneuron activity seen in Dravet mouse models. The reported deficits in the brain oscillatory activity evoked by chirp modulated tones in children with Dravet is compatible with Dravet syndrome disease mechanisms and constitutes a potential biomarker for future disease-modifying interventions. •Brain γ-oscillatory activity in sensory processing is impaired in Dravet syndrome.•Abnormal γ-activity in Dravet is consistent with deficits in GABAergic system.•Our findings are relevant for in vivo measurement of disease mechanisms in Dravet.