A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides

A pair of new tirucallane triterpenoid epimers, picraquassins M and N (1> and 2), were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their AChE inhibitory activ...

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Bibliographic Details
Published in:Chinese journal of natural medicines 2019-12, Vol.17 (12), p.906-911
Main Authors: ZHANG, Jie, WANG, Chuan-Xi, SONG, Xiao-Jun, LI, Shuang, ZHAO, Huan, CHEN, Guo-Dong, HU, Dan, GAO, Hao, YAO, Xin-Sheng
Format: Article
Language:English
Subjects:
AChE inhibitory activity
Anti-Infective Agents - chemistry
Anti-Infective Agents - isolation & purification
Antimicrobial activity
Aspergillus niger - drug effects
Candida albicans - drug effects
Cell Line, Tumor
China
Crystallography
Cytotoxicity
Epimers
Escherichia coli - drug effects
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Picrasma - chemistry
Picrasma quassioides
Plant Stems - chemistry
Staphylococcus aureus - drug effects
Tirucallane triterpenoid
Triterpenes - chemistry
Triterpenes - isolation & purification
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Summary:A pair of new tirucallane triterpenoid epimers, picraquassins M and N (1> and 2), were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their AChE inhibitory activity, cytotoxicity against five human tumour cell lines (SW480, MCF-7, HepG2, Hela, and PANC-1), and antimicrobial activity against two bacteria (Staphylococcus. aureus 209P and Escherichia coli ATCC0111) and two fungi (Candida albicans FIM709 and Aspergillus niger R330) were evaluated.
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(19)30111-6