Marked coagulopathy without liver disease or anticoagulation therapy

Symptomatic coagulopathies in celiac disease (CD) are rare. Here, we report a profound case of coagulopathy in a celiac. A 66-year old female without liver disease or anti-coagulation therapy presented with multiple ecchymoses, guaiac positive melanic stool, and a recent 4.5kg weight loss. Laborator...

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Bibliographic Details
Published in:Clinics and research in hepatology and gastroenterology 2020-10, Vol.44 (5), p.e93-e97
Main Authors: Jurgensmeier, Kevin, Hixson, Lee J., Pfeiffer, David C.
Format: Article
Language:English
Subjects:
Celiac Disease
Coagulopathy
Liver
Malabsorption
Vitamin K deficiency
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Summary:Symptomatic coagulopathies in celiac disease (CD) are rare. Here, we report a profound case of coagulopathy in a celiac. A 66-year old female without liver disease or anti-coagulation therapy presented with multiple ecchymoses, guaiac positive melanic stool, and a recent 4.5kg weight loss. Laboratory values included hemoglobin, 3.8g/dL; MCV, 66 fL; serum iron, 17μg/dL; platelet count, 580K/μL; white count, 14.2K/μL, and vitamin D,200s; prothrombin time (PT), >150s; INR, 20.5, putting her at extreme risk of bleeding. Vitamin K deficiency was assumed. The patient was given two units of fresh frozen plasma, packed red cells, and vitamin K intravenously. Endoscopy and biopsies demonstrated duodenal mucosal atrophy with cobblestoning, erosive gastritis, flattened duodenal villi and numerous intraepithelial lymphocytes. Transglutaminase serology demonstrated IgA TTG>100 U/mL (normal
ISSN:2210-7401
2210-741X
DOI:10.1016/j.clinre.2019.12.002