The Relationship between Telomere Length and Cancer Mortality: Data from the 1999–2002 National Healthy and Nutrition Examination Survey (NHANES)

Objectives The association between telomeres length (TL) and cancer mortality is uncertain. We tested the hypotheses that long TL are associated with reduced cancer mortality. Design Prospective cohort study Setting the National Health and Nutrition Survey (NHANES, 1999–2002). Participants The analy...

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Bibliographic Details
Published in:The Journal of nutrition, health & aging health & aging, 2020, Vol.24 (1), p.9-15
Main Authors: Shen, G., Huang, J.-Y., Huang, Yu-Qing, Feng, YingQing
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aging
Alcohol Drinking
Biomarkers
Blood Pressure - physiology
Body Mass Index
C-Reactive Protein - metabolism
Cancer
Cardiovascular Diseases - mortality
Chromosomes
Female
Geriatrics/Gerontology
Health risk assessment
Health Status
Humans
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Mortality
Neoplasms - mortality
Neoplasms - pathology
Neurosciences
Nutrition
Nutrition Surveys - statistics & numerical data
Older people
Primary Care Medicine
Prospective Studies
Quality of Life Research
Telomere - physiology
Telomere Shortening - physiology
United States
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Summary:Objectives The association between telomeres length (TL) and cancer mortality is uncertain. We tested the hypotheses that long TL are associated with reduced cancer mortality. Design Prospective cohort study Setting the National Health and Nutrition Survey (NHANES, 1999–2002). Participants The analytic sample included adults (n = 7183) who had TL measurements. Measurements DNA was obtained via blood samples. Telomere length was assessed using the quantitative polymerase chain reaction method. Results During follow-up (0.08–12.7 person-years, median = 9.5 years), we observed 195 participants had cancer as causes of death. TL was negatively corelated with age, body mass index (BMI), systolic blood pressure (SBP), C-reactive protein (CRP), race, diabetes, hypertension, cardiovascular diseases (CVD) and cancer mortality, conversely, positively corelated with alcohol use, but not related to diastolic blood pressure (DBP) and smoking. Kaplan-Meier analysis revealed that TL was significantly associated with cancer mortality (log-rank, P
ISSN:1279-7707
1760-4788
DOI:10.1007/s12603-019-1265-z