Prevalence of Alpha-1 Antitrypsin Deficiency in COPD Patients in Argentina. The DAAT.AR Study

INTRODUCTIONAlpha-1 antitrypsin deficiency (AATD) is still underdiagnosed, despite the recommendation to determine AAT in patients with chronic obstructive pulmonary disease (COPD). OBJECTIVETo estimate the prevalence of AATD in COPD patients adjusted according to the population of the COPD prevalen...

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Published in:Archivos de bronconeumología (English ed.) 2020-09, Vol.56 (9), p.571-577
Main Authors: Menga, Guillermo, Fernandez Acquier, Mariano, Echazarreta, Andrés L, Sorroche, Patricia B, Lorenzon, Maria V, Fernández, Martin E, Saez, María S
Format: Article
Language:eng ; spa
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Summary:INTRODUCTIONAlpha-1 antitrypsin deficiency (AATD) is still underdiagnosed, despite the recommendation to determine AAT in patients with chronic obstructive pulmonary disease (COPD). OBJECTIVETo estimate the prevalence of AATD in COPD patients adjusted according to the population of the COPD prevalence study in Argentina (EPOC.AR). MATERIAL AND METHODSThis was a multicenter prospective cross-sectional study of a population aged≥30 years of age diagnosed with COPD, involving AAT quantification in dry blood spot and subsequent genotyping in subjects with
ISSN:1579-2129
DOI:10.1016/j.arbres.2019.11.010