Prevalence of Alpha-1 Antitrypsin Deficiency in COPD Patients in Argentina. The DAAT.AR Study

INTRODUCTIONAlpha-1 antitrypsin deficiency (AATD) is still underdiagnosed, despite the recommendation to determine AAT in patients with chronic obstructive pulmonary disease (COPD). OBJECTIVETo estimate the prevalence of AATD in COPD patients adjusted according to the population of the COPD prevalen...

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Published in:Archivos de bronconeumología (English ed.) 2020-09, Vol.56 (9), p.571-577
Main Authors: Menga, Guillermo, Fernandez Acquier, Mariano, Echazarreta, Andrés L, Sorroche, Patricia B, Lorenzon, Maria V, Fernández, Martin E, Saez, María S
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container_issue 9
container_start_page 571
container_title Archivos de bronconeumología (English ed.)
container_volume 56
creator Menga, Guillermo
Fernandez Acquier, Mariano
Echazarreta, Andrés L
Sorroche, Patricia B
Lorenzon, Maria V
Fernández, Martin E
Saez, María S
description INTRODUCTIONAlpha-1 antitrypsin deficiency (AATD) is still underdiagnosed, despite the recommendation to determine AAT in patients with chronic obstructive pulmonary disease (COPD). OBJECTIVETo estimate the prevalence of AATD in COPD patients adjusted according to the population of the COPD prevalence study in Argentina (EPOC.AR). MATERIAL AND METHODSThis was a multicenter prospective cross-sectional study of a population aged≥30 years of age diagnosed with COPD, involving AAT quantification in dry blood spot and subsequent genotyping in subjects with
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The DAAT.AR Study</title><source>ScienceDirect Journals</source><creator>Menga, Guillermo ; Fernandez Acquier, Mariano ; Echazarreta, Andrés L ; Sorroche, Patricia B ; Lorenzon, Maria V ; Fernández, Martin E ; Saez, María S</creator><creatorcontrib>Menga, Guillermo ; Fernandez Acquier, Mariano ; Echazarreta, Andrés L ; Sorroche, Patricia B ; Lorenzon, Maria V ; Fernández, Martin E ; Saez, María S</creatorcontrib><description>INTRODUCTIONAlpha-1 antitrypsin deficiency (AATD) is still underdiagnosed, despite the recommendation to determine AAT in patients with chronic obstructive pulmonary disease (COPD). OBJECTIVETo estimate the prevalence of AATD in COPD patients adjusted according to the population of the COPD prevalence study in Argentina (EPOC.AR). MATERIAL AND METHODSThis was a multicenter prospective cross-sectional study of a population aged≥30 years of age diagnosed with COPD, involving AAT quantification in dry blood spot and subsequent genotyping in subjects with&lt;1.5mg/dL AAT in dry blood spot (&lt;80mg/dL in serum). AAT was defined as the detection of variants ZZ or SZ on genotyping. The EPOC.AR study population was used to calculate local adjusted prevalence. RESULTSWe included 3,254 patients (544 with AAT&lt;80mg/dL) with a spirometric diagnosis of COPD. The prevalence of AATD in the total study population was 1.29% (95% CI 0.93-1.74), of which 0.92% (95% CI 0.62-1.31) were Pi*ZZ and 0.37% (95% CI 0.19-0.64) Pi*SZ. The adjusted prevalence of AATD in COPD patients≥40 years of age was 0.83% (95% CI 0.23-2.08). We found that AATD was negatively associated with age (OR 0.94; 95% CI 0.90-0.98; P=.006), smoking habit (OR 0.98; 95% CI 0.96-0.99; P=.009), and FEV1% (OR 0.95; 95% CI 0.91-0.99; P=.015). CONCLUSIONSThe prevalence of AATD in the adult population with COPD in Argentina is estimated to be 0.83%, which could represent 17,000 cases in our country.</description><identifier>EISSN: 1579-2129</identifier><identifier>DOI: 10.1016/j.arbres.2019.11.010</identifier><language>eng ; spa</language><ispartof>Archivos de bronconeumología (English ed.), 2020-09, Vol.56 (9), p.571-577</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Menga, Guillermo</creatorcontrib><creatorcontrib>Fernandez Acquier, Mariano</creatorcontrib><creatorcontrib>Echazarreta, Andrés L</creatorcontrib><creatorcontrib>Sorroche, Patricia B</creatorcontrib><creatorcontrib>Lorenzon, Maria V</creatorcontrib><creatorcontrib>Fernández, Martin E</creatorcontrib><creatorcontrib>Saez, María S</creatorcontrib><title>Prevalence of Alpha-1 Antitrypsin Deficiency in COPD Patients in Argentina. The DAAT.AR Study</title><title>Archivos de bronconeumología (English ed.)</title><description>INTRODUCTIONAlpha-1 antitrypsin deficiency (AATD) is still underdiagnosed, despite the recommendation to determine AAT in patients with chronic obstructive pulmonary disease (COPD). OBJECTIVETo estimate the prevalence of AATD in COPD patients adjusted according to the population of the COPD prevalence study in Argentina (EPOC.AR). MATERIAL AND METHODSThis was a multicenter prospective cross-sectional study of a population aged≥30 years of age diagnosed with COPD, involving AAT quantification in dry blood spot and subsequent genotyping in subjects with&lt;1.5mg/dL AAT in dry blood spot (&lt;80mg/dL in serum). AAT was defined as the detection of variants ZZ or SZ on genotyping. The EPOC.AR study population was used to calculate local adjusted prevalence. RESULTSWe included 3,254 patients (544 with AAT&lt;80mg/dL) with a spirometric diagnosis of COPD. The prevalence of AATD in the total study population was 1.29% (95% CI 0.93-1.74), of which 0.92% (95% CI 0.62-1.31) were Pi*ZZ and 0.37% (95% CI 0.19-0.64) Pi*SZ. The adjusted prevalence of AATD in COPD patients≥40 years of age was 0.83% (95% CI 0.23-2.08). We found that AATD was negatively associated with age (OR 0.94; 95% CI 0.90-0.98; P=.006), smoking habit (OR 0.98; 95% CI 0.96-0.99; P=.009), and FEV1% (OR 0.95; 95% CI 0.91-0.99; P=.015). 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The DAAT.AR Study</title><author>Menga, Guillermo ; Fernandez Acquier, Mariano ; Echazarreta, Andrés L ; Sorroche, Patricia B ; Lorenzon, Maria V ; Fernández, Martin E ; Saez, María S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p188t-2f48d0f760ab2c8493bd66e086b1ee077d5c976f2f6c18aa0562f105ad7b728c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; spa</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Menga, Guillermo</creatorcontrib><creatorcontrib>Fernandez Acquier, Mariano</creatorcontrib><creatorcontrib>Echazarreta, Andrés L</creatorcontrib><creatorcontrib>Sorroche, Patricia B</creatorcontrib><creatorcontrib>Lorenzon, Maria V</creatorcontrib><creatorcontrib>Fernández, Martin E</creatorcontrib><creatorcontrib>Saez, María S</creatorcontrib><collection>MEDLINE - Academic</collection><jtitle>Archivos de bronconeumología (English ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Menga, Guillermo</au><au>Fernandez Acquier, Mariano</au><au>Echazarreta, Andrés L</au><au>Sorroche, Patricia B</au><au>Lorenzon, Maria V</au><au>Fernández, Martin E</au><au>Saez, María S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of Alpha-1 Antitrypsin Deficiency in COPD Patients in Argentina. The DAAT.AR Study</atitle><jtitle>Archivos de bronconeumología (English ed.)</jtitle><date>2020-09-01</date><risdate>2020</risdate><volume>56</volume><issue>9</issue><spage>571</spage><epage>577</epage><pages>571-577</pages><eissn>1579-2129</eissn><abstract>INTRODUCTIONAlpha-1 antitrypsin deficiency (AATD) is still underdiagnosed, despite the recommendation to determine AAT in patients with chronic obstructive pulmonary disease (COPD). OBJECTIVETo estimate the prevalence of AATD in COPD patients adjusted according to the population of the COPD prevalence study in Argentina (EPOC.AR). MATERIAL AND METHODSThis was a multicenter prospective cross-sectional study of a population aged≥30 years of age diagnosed with COPD, involving AAT quantification in dry blood spot and subsequent genotyping in subjects with&lt;1.5mg/dL AAT in dry blood spot (&lt;80mg/dL in serum). AAT was defined as the detection of variants ZZ or SZ on genotyping. The EPOC.AR study population was used to calculate local adjusted prevalence. RESULTSWe included 3,254 patients (544 with AAT&lt;80mg/dL) with a spirometric diagnosis of COPD. The prevalence of AATD in the total study population was 1.29% (95% CI 0.93-1.74), of which 0.92% (95% CI 0.62-1.31) were Pi*ZZ and 0.37% (95% CI 0.19-0.64) Pi*SZ. The adjusted prevalence of AATD in COPD patients≥40 years of age was 0.83% (95% CI 0.23-2.08). We found that AATD was negatively associated with age (OR 0.94; 95% CI 0.90-0.98; P=.006), smoking habit (OR 0.98; 95% CI 0.96-0.99; P=.009), and FEV1% (OR 0.95; 95% CI 0.91-0.99; P=.015). CONCLUSIONSThe prevalence of AATD in the adult population with COPD in Argentina is estimated to be 0.83%, which could represent 17,000 cases in our country.</abstract><doi>10.1016/j.arbres.2019.11.010</doi><tpages>7</tpages></addata></record>
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