Dietary intake of polyphenols and risk of colorectal cancer and adenoma–A case-control study from Iran

•Polyphenols from 80 food items were derived from an update version of phenol explorer database (www.phenol-explorer.eu).•High intake of flavonols, total phenolic acids and hydroxicinamic acids could be related to a decreased risk of CRC.•High consumption of total polyphenols, total flavonoids and f...

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Published in:Complementary therapies in medicine 2019-08, Vol.45, p.269-274
Main Authors: Bahrami, Alireza, Jafari, Saeede, Rafiei, Pegah, Beigrezaei, Sara, Sadeghi, Amir, Hekmatdoost, Azita, Rashidkhani, Bahram, Hejazi, Ehsan
Format: Article
Language:English
Subjects:
Acids
Adenoma
Adenoma - prevention & control
Age
Cancer
Case-Control Studies
Colorectal adenoma
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - prevention & control
Comorbidity
Confidence intervals
Diet
Dietary intake
Dietary supplements
Family medical history
Female
Flavanols
Flavonoids
Flavonoids - administration & dosage
Food
Health risks
Humans
Hydroxybenzoates - administration & dosage
Iran
Life Style
Lignan
Male
Middle Aged
Mortality
Odds Ratio
Phenolic acids
Phenols
Polyphenol
Polyphenols
Polyphenols - administration & dosage
Questionnaires
Risk
Risk Factors
Software
Tumors
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Summary:•Polyphenols from 80 food items were derived from an update version of phenol explorer database (www.phenol-explorer.eu).•High intake of flavonols, total phenolic acids and hydroxicinamic acids could be related to a decreased risk of CRC.•High consumption of total polyphenols, total flavonoids and flavanols were inversely associated with the risk of CRA. The aim of this study is to examine the relationship between dietary polyphenols’ classes and individual polyphenol subclasses and also the risk of Colorectal cancer (CRC) and colorectal adenomas (CRA). A hospital-based case-control study on the association between CRC and CRA and dietary polyphenols was conducted. Overall, 129 colorectal cancers, 130 colorectal adenoma cases and 240 healthy controls were studied in three major general hospitals in Tehran province, Iran. In a multivariate-adjusted model for potential confounders, higher consumption of stilbenes (OR 0.49 for the highest vs. the lowest quartile; 95% CI = 0.24−0.99; p for trend = 0.013) was associated with the decreased risk of CRA. Moreover, an inverse association between the risk of CRC and the intake of total polyphenols (OR 0.05 for the highest vs. the lowest quartile; 95% CI = 0.01−0.19; p for trend=
ISSN:0965-2299
1873-6963
DOI:10.1016/j.ctim.2019.04.011