Albumin-bilirubin score is associated with response to pegylated interferon and nucleos(t)ide analogues in chronic hepatitis B patients

• Published in: Clinica chimica acta 2020-03, Vol.502, p.120-127
• Main Authors: Xun, Zhen, Liu, Can, Yu, Qing-Qing, Lin, Jin-Piao, Huang, Jin-Lan, Yang, Ting-Wen, Wu, Wen-Nan, Wu, Song-Hang, Ou, Qi-Shui
• Format: Article
• Language: English
• Subjects: Albumin-bilirubin; Chronic hepatitis B; Natural history; Nucleos(t)ide analogues; Pegylated interferon; Treatment response
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2019.12.020

•ALBI score differs significantly across the natural course of chronic HBV infection.•Patients with high ALBI score have a stronger PEG-IFN-α and NAs treatment response.•Patients with ALBI grade 2 have a persistently higher rate of HBeAg and HBsAg loss.•ALBI score is an independent predictor of sustained response achievement. Recently, the role of albumin-bilirubin (ALBI) score in chronic hepatitis B (CHB) has not been well-understood. We aimed to investigate the association of ALBI score with natural history of chronic HBV infection and treatment response of CHB patients. The ALBI score in a cohort of 849 individuals including 721 chronic HBV-infected patients naïve to anti-HBV treatment in different phases and 128 healthy controls were estimated. Additionally, the dynamic changes of ALBI score of 243 hepatitis B e antigen (HBeAg)-positive CHB patients treated with pegylated interferon-alpha (PEG-IFN-α) or nucleos(t)ide analogues (NAs) were tested for 72 weeks. ALBI score differed among phases, with the highest score in HBeAg-positive CHB patients, followed by HBeAg-negative CHB patients, HBeAg-positive chronic HBV infection, and HBeAg-negative chronic HBV infection. Besides, CHB patients harbouring high baseline ALBI score exhibited a relatively stronger therapeutic response to PEG-IFN-α or NAs. Moreover, the rate of HBeAg and HBsAg loss in patients with ALBI grade 2 was persistently higher than that in patients with ALBI grade 1 throughout the course of treatment. Furthermore, ALBI score was an independent predictor of sustained response achievement. The combined use of ALBI score, HBeAg and ALT could enhance the predictive value of treatment response. ALBI score differed significantly across the natural course of chronic HBV infection and was correlated with PEG-IFN-α and NAs treatment response in HBeAg-positive CHB patients, which suggested that ALBI score could be useful as an auxiliary clinical factor to determine the initiation of therapy and predict stronger antiviral treatment response.