Differentiating keratoacanthoma from squamous cell carcinoma—In quest of the holy grail

To distinguish keratoacanthomas from squamous cell carcinomas remains a diagnostic challenge in dermatopathology. Several immunohistochemical and cytogenetic markers have been evaluated; however, so far there has been no unequivocal evidence supporting practical application of any of these markers....

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Bibliographic Details
Published in:Journal of cutaneous pathology 2020-04, Vol.47 (4), p.418-420
Main Author: Nagarajan, Priyadharsini
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - metabolism
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
CD123
CD123 antigen
Cell differentiation
Cytogenetics
Dendritic cells
Dendritic Cells - metabolism
Dendritic Cells - pathology
Diagnosis, Differential
Humans
Interleukin-3 Receptor alpha Subunit - metabolism
keratoacanthoma
Keratoacanthoma - diagnosis
Keratoacanthoma - metabolism
Keratoacanthoma - pathology
Neoplasm Proteins - metabolism
plasmacytoid dendritic cells
Skin Neoplasms - diagnosis
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
Squamous cell carcinoma
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Summary:To distinguish keratoacanthomas from squamous cell carcinomas remains a diagnostic challenge in dermatopathology. Several immunohistochemical and cytogenetic markers have been evaluated; however, so far there has been no unequivocal evidence supporting practical application of any of these markers. Recent studies have evaluated the composition of tumor‐associated immune infiltrate, in particular the number and distribution of CD123‐positive plasmacytoid dendritic cells in making this distinction; but these cells also do not appear to be a consistent biomarker in distinguishing keratoacanthoma from squamous cell carcinoma.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.13640