Platelet-derived miRNAs as determinants of the antiplatelet response in clopidogrel-treated patients with ACS

•Platelet microRNAs were screened for links with platelet reactivity in healthy subjects.•The associated microRNAs were validated in clopidogrel-treated patients with ACS.•Platelet miR-223/126/150 influenced the clopidogrel antiplatelet effect.

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Bibliographic Details
Published in:Thrombosis research 2020-02, Vol.186, p.71-74
Main Authors: Liu, Jun, Qin, Liuan, Wang, Ziqian, Peng, Li, Liu, Jia, Wang, Xuyun, Du, Rina, Zou, Yuting, Wu, Yangxun, Yin, Tong
Format: Article
Language:English
Subjects:
Acute coronary syndrome
Clopidogrel
microRNAs
Platelet reactivity
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Description
Summary:•Platelet microRNAs were screened for links with platelet reactivity in healthy subjects.•The associated microRNAs were validated in clopidogrel-treated patients with ACS.•Platelet miR-223/126/150 influenced the clopidogrel antiplatelet effect.
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2019.12.016